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- 71 Good food
- 74 On time delivery
- 70 Correct order
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Main attractions, sodas and juices, frozen drinks, seared sea scallops, loaded fries, chicken bites, crispy fried calamari, caribben shrimp, the lit 21 wings, camarones al ajillo, volcanic nachos, 5 star vip sampler, piggyback fries, fried mozzarella, colomabian style empanadas, fresh guacamole, garlic pesto flatbread, chorizo flatbread, crispy chicken fingers, lit 21 wings, tostones cup, bang bang shrimp, quesadillas, chicken fingers, chicken cobb salad, the lit 21 house salad, steak salad, over the top taco salad, seared tuna salad, green sea salad, sancocho de pollo soup, french onion soup, azteca soup, chick noodle soup, wild buffalo wrap, high protein wrap, chicken and avocado wrap, steak and chicken wrap, fried fish sandwich, top shelf steak sandwich, pork blt sandwich, chicken sandwich, chicken strip melt, cuban sandwich, braised short rib sandwich, turkey club, the all american burger, the don burger, home-made veggie burger, beef sliders, buffalo sliders, build your own my burger, smokehouse burger, avocado bison burger, teriyaki turkey burger, the lit 21 burger, double grilled cheeseburger, chicken murphy, sauteed salmon, hickory-smoked beef short ribs, 1 by lanf 2 by sea, fettuccini alfredo, top sirloin steak, tilapia and shrimp, shrimp trio, arroz chaufa, grilled pork chops, penne vodka with shrimp, surf and turf, gluten free new york steak, grilled tilapia with spinach and asparagus, cheeseburger, chicken breast, steak diane, mango guava cheesecake, churro cake, tuxedo bombe, double nutty chocolate brownie.
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Pineapple Juice
Lemonade juice, pink lemonade, cranberry juice, orange juice, lobster mac & cheese, pan-seared entrees, blackened chicken alfredo pasta, calabrese shrimp pasta, chimichurri skirt steak, surf & turf, lit 21 burger, macaroni & cheese, hand cut fries, cajun fries, yucca fries, mexicano street corn, grilled asparagus, mashed potatoes, vegetable saffron rice, sauteed vegetables, sweet potato fries, lit 21 bulldog, henny colada, pina colada, vodka lemonade, the lit 21 jack danielâs punch, bacardi mermaid bucket, lit 21 menu info, sponsored restaurants in your area.
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Reviews for lit 21, q) does lit 21 (1034 mccarter hwy) deliver, q) does lit 21 (1034 mccarter hwy) offer contact-free delivery, q) is lit 21 (1034 mccarter hwy) eligible for seamless+ free delivery.
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1034 McCarter Highway 07102 Newark New Jersey
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Food and ambience, location and contact, lit 21, newark - restaurant reviews - tripadvisor.
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Lit 21 (Newark, NJ): Address, Phone Number - Tripadvisor
Customer Ratings and Reviews
Ordered food from Lit21 for the first time tonight. I used their website to order. It wasnt complicated. Easy to use. At the end they give you an estimated arrival time which is dope. Food got here before estimated time which was great! We tried the arroz chaufa with chicken and shrimp and some burgers. All the food was delicious! The wings were good too. Burgers on point. Pleasantly surprised! Food hit the spot ????!
Had a Blast here with my friends!! Great vibes and lots of space. Music was on point. Dress code was enforced and everyone looked great! Grown and sexy atmosphere. Free for ladies on a Saturday canât best that !!!
Lit 21 is a great place for every type of plan you have in mind, want to chill and play with friends while eating and drinking? Go there, great food, amazing staff, great view at the patio, and the nightclub!? The vibe is great, their security is the best! I feel safe there all the time ????????
Nice bar/restaurant on the border of Newark and Harrison, not easy to get to by mass transit so plan on driving. The food is pretty good the two times I've been, especially given the price. From my experience it can range from nearly empty early on weekends to packed on weekdays after work, to the point you'll be waiting a while for your cheque. The servers are great though, very personable and attentive, just a bit overworked.
Soon as I walk in the place was nice. The waiters was very respectful and helpful. The only thing about it that they didn't play the music I like. I enjoyed my Birthday with family and friends. It was clean, the food was good and I will visit again????
Photos of Lit 21
![Lit 21 | night club | 1034 McCarter Hwy, Newark, NJ 07102, USA | 9737182646 OR +1 973-718-2646 Lit 21 | night club | 1034 McCarter Hwy, Newark, NJ 07102, USA | 9737182646 OR +1 973-718-2646](https://cdn.usarestaurants.info/assets/uploads/ba90b433d929abcd619fb65f39e6c92c_-united-states-new-jersey-essex-county-newark-lit-21-973-718-2646htm.jpg)
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Lit 21 Sports Bar and Lounge to Open This Week along Route 21 in Newark
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Borders Tex-Mex Cantina advertised that it was the “perfect spot” for graduation celebrations this year. However, the Downtown Newark restaurant, which opened for business two months after the school year began, ended up closing its doors before students in Essex County even took their final exams. Now, following the closure of the cityâs only sit-down Tex-Mex restaurant, another business is preparing to open inside.
Lit 21 will soon be in operation in the space, which is located at 1034 McCarter Highway near the Bridge Street Bridge. The business, which describes itself a restaurant, sports bar, and lounge that is “the hottest venue in the tri-state area,” has announced that it will hold a grand opening celebration with DJ Camilo of HOT 97 on Thursday, June 27.
View this post on Instagram The hottest venue has arrived. @lit21nj See you at the Grand opening! June 27thđĽNo cover charge. . . . . . . #Newark #Newyork #eatchillplay #nightlife #party #grandopening #fiesta #summer2019 #litlife A post shared by LIT 21 (@lit21nj) on Jun 21, 2019 at 2:26pm PDT
The facade of the building was recently painted and a new sign was installed in front. Lit 21âs logo and name reflect the spaceâs location along Route 21. Few other details are known yet about the establishment. A representative of Lit 21 could not be reached for comment.
Once home to Rio Rodizio, this restaurant space is one of only a few in Downtown Newark that includes a free surface parking lot for customers, through Lit 21âs Facebook page mentions that there will also be valet parking. Located along a busy state highway, there is not heavy pedestrian traffic in this area, but as we reported when Borders opened, that could change in the years to come if the expansion of Riverfront Park and the construction of the Riverfront Square development move forward.
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- 71 Good food
- 74 On time delivery
- 70 Correct order
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Main attractions, sodas and juices, frozen drinks, seared sea scallops, loaded fries, chicken bites, crispy fried calamari, caribben shrimp, the lit 21 wings, camarones al ajillo, volcanic nachos, 5 star vip sampler, piggyback fries, fried mozzarella, colomabian style empanadas, fresh guacamole, garlic pesto flatbread, chorizo flatbread, crispy chicken fingers, lit 21 wings, tostones cup, bang bang shrimp, quesadillas, chicken fingers, chicken cobb salad, the lit 21 house salad, steak salad, over the top taco salad, seared tuna salad, green sea salad, sancocho de pollo soup, french onion soup, azteca soup, chick noodle soup, wild buffalo wrap, high protein wrap, chicken and avocado wrap, steak and chicken wrap, fried fish sandwich, top shelf steak sandwich, pork blt sandwich, chicken sandwich, chicken strip melt, cuban sandwich, braised short rib sandwich, turkey club, the all american burger, the don burger, home-made veggie burger, beef sliders, buffalo sliders, build your own my burger, smokehouse burger, avocado bison burger, teriyaki turkey burger, the lit 21 burger, double grilled cheeseburger, chicken murphy, sauteed salmon, hickory-smoked beef short ribs, 1 by lanf 2 by sea, fettuccini alfredo, top sirloin steak, tilapia and shrimp, shrimp trio, arroz chaufa, grilled pork chops, penne vodka with shrimp, surf and turf, gluten free new york steak, grilled tilapia with spinach and asparagus, cheeseburger, chicken breast, steak diane, mango guava cheesecake, churro cake, tuxedo bombe, double nutty chocolate brownie.
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Pineapple Juice
Lemonade juice, pink lemonade, cranberry juice, orange juice, lobster mac & cheese, pan-seared entrees, blackened chicken alfredo pasta, calabrese shrimp pasta, chimichurri skirt steak, surf & turf, lit 21 burger, macaroni & cheese, hand cut fries, cajun fries, yucca fries, mexicano street corn, grilled asparagus, mashed potatoes, vegetable saffron rice, sauteed vegetables, sweet potato fries, lit 21 bulldog, henny colada, pina colada, vodka lemonade, the lit 21 jack danielâs punch, bacardi mermaid bucket, lit 21 menu info, sponsored restaurants in your area.
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Reviews for lit 21, q) does lit 21 (1034 mccarter hwy) deliver, q) does lit 21 (1034 mccarter hwy) offer contact-free delivery, q) is lit 21 (1034 mccarter hwy) eligible for grubhub+ free delivery.
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LIT 21, Newark - Restaurant Reviews, Food Delivery & Takeaway - Tripadvisor
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Ratings and reviews
Food and ambience, location and contact, lit 21, newark - restaurant reviews, food delivery & takeaway - tripadvisor.
Hours updated 3 months ago
![lit 21 reviews Photo of Lit Lounge - San Leandro, CA, US. Turnt Lotus and Mango Margarita](https://s3-media0.fl.yelpcdn.com/bphoto/0hOyYgn7bwdc4sLenKM7bQ/l.jpg)
Today is a holiday! Business hours may be different today.
Review Highlights
![lit 21 reviews Elaine A.](https://s3-media0.fl.yelpcdn.com/assets/public/user_60_square.yji-b98a858bc39bdfe99ecc.png)
â I arrived there by myself and the bartender, Joshua , was very friendly and accommodating playing music that other customers requested. â in 2 reviews
![lit 21 reviews Ellie M.](https://s3-media0.fl.yelpcdn.com/photo/K5A9LQoZOvyStqFX1gk7_g/60s.jpg)
â Went for a drink with my cousin and was pleasantly surprised. â in 2 reviews
![lit 21 reviews Marina R.](https://s3-media0.fl.yelpcdn.com/photo/mOnzzoARQLMwGPLEx6tUww/60s.jpg)
â I will also suggest they get a game or two maybe some Jenga in there so they can put some good use to the tables :) .. They have popcorn as a snack I didn't have any though. â in 2 reviews
Location & Hours
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![lit 21 reviews Map](https://maps.googleapis.com/maps/api/staticmap?size=315x150&sensor=false&client=gme-yelp&language=en&scale=1&zoom=15¢er=37.685633%2C-122.139321&markers=scale%3A1%7Cicon%3Ahttps%3A%2F%2Fyelp-images.s3.amazonaws.com%2Fassets%2Fmap-markers%2Fannotation_32x43.png%7C37.685633%2C-122.139321&signature=EE0AWAToT9lc48b8cC9UbWJWuEo=)
15325 Washington Ave
San Leandro, CA 94579
Lorenzo Ave & Lewelling Blvd
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Overall rating
![lit 21 reviews Photo of Tina A.](https://s3-media0.fl.yelpcdn.com/photo/QI_J7XDp5TM-JguaWvTq6g/60s.jpg)
Definitely 2000-2010's bay area party vibes. It felt highly nostalgic with the music videos playing hip hop and RnB, along with the caffeinated liquor options and flavored vodka options Got the Margarita and the lotus drink, both were terrible and highly reminiscent of clubbing in SF in the early days. Over sugary and not that strong, poorly balanced. Nothing like whatever the previous yelpers with fancy cocktails and craft beer posted. If you're looking for a good cocktail you can go to viridian in Oakland and get something really good for similar prices but this here you can have a reminder of the sticky club floors and your crazy days Atmosphere here was clean and nostalgic, especially the black toilets, music and drinks. Overall would only probably come back here if they had a DJ or a dance night
![lit 21 reviews Turnt Lotus and Mango Margarita](https://s3-media0.fl.yelpcdn.com/bphoto/0hOyYgn7bwdc4sLenKM7bQ/348s.jpg)
Turnt Lotus and Mango Margarita
![lit 21 reviews Menu](https://s3-media0.fl.yelpcdn.com/bphoto/Ug3277GfhWPhZ4TeGsXl0A/348s.jpg)
Mary was awesome and super hospitable, the lounge has a great vibe. The drinks were mixed really well.
![lit 21 reviews Photo of Ellie M.](https://s3-media0.fl.yelpcdn.com/photo/K5A9LQoZOvyStqFX1gk7_g/60s.jpg)
Cute new bar in San Lorenzo. Went for a drink with my cousin and was pleasantly surprised. The vibe is cool not crazy hectic. The bartender is attentive! They got a popcorn machine! Cute. They play a good mix of music too! Various TVs on the wall playing music videos. Little space to dance if it get crowded. Overall I thought it was a vibe.
![lit 21 reviews](https://s3-media0.fl.yelpcdn.com/bphoto/fJ0Dh_YpLmIEfYxQPTQ6lA/348s.jpg)
See all photos from Ellie M. for Lit Lounge
![lit 21 reviews Photo of Celeste F.](https://s3-media0.fl.yelpcdn.com/photo/mKX9PXtslmK96_iktDAXOg/60s.jpg)
I come for the free popcorn lol but no seriously it's a cool spot for some drinks and good (loud) music. Can get pretty busy sometimes, it's a hit or miss.
![lit 21 reviews Joshua-great bartender](https://s3-media0.fl.yelpcdn.com/bphoto/4lOeGTKaXIJWvDm67pvf7g/348s.jpg)
Joshua-great bartender
![lit 21 reviews Photo of Omar A.](https://s3-media0.fl.yelpcdn.com/photo/yjr3DkpBJiQPXvTbVmKI9A/60s.jpg)
Stopped by on a quiet Monday night with my girlfriend, and was not disappointed! The bartender who was working, Joshua (had a necklace with his name so can't get it wrong) was friendly and attentive, resulting in an overall relaxing night with good conversation. The entire establishment was extremely clean, including the restroom Can't complain about drinks, we ordered the basics, a couple beers and some whiskey on the rocks but next time we will try some of their signature drinks. We will definitely come back soon, we actually have an invitation to a birthday party here for next month, so we're glad to have seen the place before then and are looking forward to it. Stay lit!
![lit 21 reviews](https://s3-media0.fl.yelpcdn.com/bphoto/AMkj5tWXXGVlN0oS7sg30g/348s.jpg)
Cool atmosphere and call employees. Parkin lot small but it's good. Get there before the fake thugs show up to show out for no reason
![lit 21 reviews Photo of Tessie L.](https://s3-media0.fl.yelpcdn.com/photo/Aoyn03465jPtjfUYVfQUAw/60s.jpg)
Not happy with the bartender at Lit never smiled, wasn't a nice one and I did not like that guy at all I will never return again - Sorry Lit Looks nice inside and the vibe was good just get another Bartender who likes people!!
![lit 21 reviews Photo of Britney V.](https://s3-media0.fl.yelpcdn.com/photo/alSR7rl9VZr08Sid-EQw_Q/60s.jpg)
I loooove to check out new bars in town. I stopped by 7/8 to check out the new renovation and name change of this bar. I used to come here years ago when it was the Victorian Pub. Sooo glad someone finally renovated this place. It looks super modern and hip now. Love all the decor and big TV's. The bar looks BEAUTIFUL. And is definitely great for groups and young people that love to take selfies in front of cute backgrounds. Only downside I noticed was that the bar was dead. And there was a lack of genuine hospitality. I walked in the door and wasn't greeted warmly, in a timely manner, nor did I feel welcome. There was NO vibe at all. Anyways, I introduced myself to Owner Josh but it seemed he was too busy chatting up some girl at the bar which is fine. But I had came in this bar in hopes to help his business. Perhaps offer to help with some event planning and social media marketing here and bring in more business or bring a DJ, karaoke, food vendors, game night, singles night etc. For someone that works in hospitality/customer service as well as loves to help promote new businesses. This one is just lacking in the hospitality department for me. As a bartender I always say "Anybody can make a drink, just gotta know how to serve it. Have people leaving better than they came". I'll try this bar 1 more time in a few months, in hopes that they up the hospitality.
![lit 21 reviews Great photo op area to take selfies with your crew](https://s3-media0.fl.yelpcdn.com/bphoto/UfvXcFBLcGS96KlWTnEvCg/348s.jpg)
Great photo op area to take selfies with your crew
![lit 21 reviews](https://s3-media0.fl.yelpcdn.com/bphoto/iTWE445gtFDInxvqMjWDYw/348s.jpg)
Whack. It has no vibe. It's boring. It's a plain dive bar that has no food and just is average.
![lit 21 reviews Photo of Zeydi J.](https://s3-media0.fl.yelpcdn.com/assets/public/default_user_avatar_64x64_v2.yji-19e0a8ff85b15f4bbd79.png)
From service to bad drinks man very disappointed the guy with tattoos was just wort customer service don't go there .
![lit 21 reviews](https://s3-media0.fl.yelpcdn.com/bphoto/H4C7wa3u3y277yeY2mkE9g/348s.jpg)
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Andrea M. said "Much to my disgust, despite me reading the bad reviews about the service on this place to the boy, he still wants to go here for dinner on an early Saturday night. We go, I expect really bad service and meh food. While it took themâŚ" read more
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Joyce Carol Oatesâ Butcher , R.O. Kwonâs Exhibit , Daniel Handlerâs And Then? and Then? What Else? , and Kevin Kwanâs Lies and Weddings all feature among the best reviewed books of the week.
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âThe book has the feverish energy, narrative propulsion and descriptive amplitudeâsometimes to excessâof much of her earlier work ⌠Undoubtedly one of her most surreal and gruesome works, sparing no repulsive detail or nefarious impulse. In the end, though, the purview of the novel is larger than one might think, becoming an empathic and discerning commentary on womenâs rights, the abuses of patriarchy and the servitude of the poor and disenfranchised. Oates, as is her wont, succeeds in creating a world that is apart from our own yet familiar, making it impossible to dismiss her observations about twisted natures and random acts of violence.â
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2. Exhibit by R.O. Kwon (Riverhead)
3 Rave ⢠3 Positive ⢠1 Mixed Read an interview with R.O. Kwon here
âSome readers might sour at the inconclusive ending. But in my mind, nothing is more appropriate for a novel about religionâs hauntings, about religion and art and desire overrunning language and all its forms, including the novel. Kwon understands that these stories cannot have clean endings because something always escapes the telling. We end up silent, tense, gesturing, pointing.â
âRyan Lackey ( The Los Angeles Review of Books )
3. Lies and Weddings by Kevin Kwan (Doubleday)
2 Rave ⢠3 Positive ⢠1 Mixed Read an interview with Kevin Kwan here
â Lies and Weddings is chock-full of scheming characters and breathtakingly lavish scenes ⌠Kwan remains a cheekily hilarious writer, with footnotes that give each chapter an extra kick ⌠Pure pleasure.â
âAmy Scribner ( BookPage )
1. Undue Burden: Life and Death Decisions in Post-Roe America by Shefali Luthra (Doubleday)
5 Rave ⢠1 Positive
â Undue Burden isnât the first book about abortion rights and it certainly wonât be the last. But one quality that sets it apart is that it offers accounts from all types of people in all types of circumstances ⌠Some of the most affecting sections are those in which Luthra details some of the struggles marginalized patients are going through to access essential reproductive care.â
âAlexis Burling ( The San Francisco Chronicle )
2. And Then? and Then? What Else? by Daniel Handler (Liveright)
3 Rave ⢠3 Positive
â And Then? And Then? What Else? is a bit of a grab bag, starting in the middle and ending in the middle, while telling a series of stories that both connect and overlap ⌠Handler is skilled and nuanced as a writer, with a developed voice and point of view. He has never fit the categories, so why would we expect him to start here? ⌠He is frank without being overly revealing and always seeks out some larger integration, a place where thought and feeling might intersect.â
âDavid L. Ulin ( The Los Angeles Times )
3. In My Time of Dying: How I Came Face to Face with the Idea of an Afterlife by Sebastian Junger (Simon & Schuster)
2 Rave ⢠2 Positive
âJunger combines riveting operating-room drama, flush with detailed anatomical explanations, with vivid switchbacks to dangerous adventures in his past as well as forays into medical history, his physicist fatherâs life, quantum mechanics, and the universal elements of near-death experiences. Tracing the ever-wavering lines between science and mystery, reason and spirituality, Junger grapples with the complexity of the brain, the riddle of consciousness, and our views of death. Ardently researched, consummately written, and boldly forthright, this an intensely moving and deeply provocative immersion.â
âDonna Seaman ( Booklist )
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A systematic literature review of empirical research on ChatGPT in education
- Open access
- Published: 26 May 2024
- Volume 3 , article number 60 , ( 2024 )
Cite this article
You have full access to this open access article
- Yazid Albadarin  ORCID: orcid.org/0009-0005-8068-8902 1 ,
- Mohammed Saqr 1 ,
- Nicolas Pope 1 &
- Markku Tukiainen 1 Â
Over the last four decades, studies have investigated the incorporation of Artificial Intelligence (AI) into education. A recent prominent AI-powered technology that has impacted the education sector is ChatGPT. This article provides a systematic review of 14 empirical studies incorporating ChatGPT into various educational settings, published in 2022 and before the 10th of April 2023âthe date of conducting the search process. It carefully followed the essential steps outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines, as well as Okoliâs (Okoli in Commun Assoc Inf Syst, 2015) steps for conducting a rigorous and transparent systematic review. In this review, we aimed to explore how students and teachers have utilized ChatGPT in various educational settings, as well as the primary findings of those studies. By employing Creswellâs (Creswell in Educational research: planning, conducting, and evaluating quantitative and qualitative research [Ebook], Pearson Education, London, 2015) coding techniques for data extraction and interpretation, we sought to gain insight into their initial attempts at ChatGPT incorporation into education. This approach also enabled us to extract insights and considerations that can facilitate its effective and responsible use in future educational contexts. The results of this review show that learners have utilized ChatGPT as a virtual intelligent assistant, where it offered instant feedback, on-demand answers, and explanations of complex topics. Additionally, learners have used it to enhance their writing and language skills by generating ideas, composing essays, summarizing, translating, paraphrasing texts, or checking grammar. Moreover, learners turned to it as an aiding tool to facilitate their directed and personalized learning by assisting in understanding concepts and homework, providing structured learning plans, and clarifying assignments and tasks. However, the results of specific studies (nâ=â3, 21.4%) show that overuse of ChatGPT may negatively impact innovative capacities and collaborative learning competencies among learners. Educators, on the other hand, have utilized ChatGPT to create lesson plans, generate quizzes, and provide additional resources, which helped them enhance their productivity and efficiency and promote different teaching methodologies. Despite these benefits, the majority of the reviewed studies recommend the importance of conducting structured training, support, and clear guidelines for both learners and educators to mitigate the drawbacks. This includes developing critical evaluation skills to assess the accuracy and relevance of information provided by ChatGPT, as well as strategies for integrating human interaction and collaboration into learning activities that involve AI tools. Furthermore, they also recommend ongoing research and proactive dialogue with policymakers, stakeholders, and educational practitioners to refine and enhance the use of AI in learning environments. This review could serve as an insightful resource for practitioners who seek to integrate ChatGPT into education and stimulate further research in the field.
Avoid common mistakes on your manuscript.
1 Introduction
Educational technology, a rapidly evolving field, plays a crucial role in reshaping the landscape of teaching and learning [ 82 ]. One of the most transformative technological innovations of our era that has influenced the field of education is Artificial Intelligence (AI) [ 50 ]. Over the last four decades, AI in education (AIEd) has gained remarkable attention for its potential to make significant advancements in learning, instructional methods, and administrative tasks within educational settings [ 11 ]. In particular, a large language model (LLM), a type of AI algorithm that applies artificial neural networks (ANNs) and uses massively large data sets to understand, summarize, generate, and predict new content that is almost difficult to differentiate from human creations [ 79 ], has opened up novel possibilities for enhancing various aspects of education, from content creation to personalized instruction [ 35 ]. Chatbots that leverage the capabilities of LLMs to understand and generate human-like responses have also presented the capacity to enhance student learning and educational outcomes by engaging students, offering timely support, and fostering interactive learning experiences [ 46 ].
The ongoing and remarkable technological advancements in chatbots have made their use more convenient, increasingly natural and effortless, and have expanded their potential for deployment across various domains [ 70 ]. One prominent example of chatbot applications is the Chat Generative Pre-Trained Transformer, known as ChatGPT, which was introduced by OpenAI, a leading AI research lab, on November 30th, 2022. ChatGPT employs a variety of deep learning techniques to generate human-like text, with a particular focus on recurrent neural networks (RNNs). Long short-term memory (LSTM) allows it to grasp the context of the text being processed and retain information from previous inputs. Also, the transformer architecture, a neural network architecture based on the self-attention mechanism, allows it to analyze specific parts of the input, thereby enabling it to produce more natural-sounding and coherent output. Additionally, the unsupervised generative pre-training and the fine-tuning methods allow ChatGPT to generate more relevant and accurate text for specific tasks [ 31 , 62 ]. Furthermore, reinforcement learning from human feedback (RLHF), a machine learning approach that combines reinforcement learning techniques with human-provided feedback, has helped improve ChatGPTâs model by accelerating the learning process and making it significantly more efficient.
This cutting-edge natural language processing (NLP) tool is widely recognized as one of today's most advanced LLMs-based chatbots [ 70 ], allowing users to ask questions and receive detailed, coherent, systematic, personalized, convincing, and informative human-like responses [ 55 ], even within complex and ambiguous contexts [ 63 , 77 ]. ChatGPT is considered the fastest-growing technology in history: in just three months following its public launch, it amassed an estimated 120 million monthly active users [ 16 ] with an estimated 13 million daily queries [ 49 ], surpassing all other applications [ 64 ]. This remarkable growth can be attributed to the unique features and user-friendly interface that ChatGPT offers. Its intuitive design allows users to interact seamlessly with the technology, making it accessible to a diverse range of individuals, regardless of their technical expertise [ 78 ]. Additionally, its exceptional performance results from a combination of advanced algorithms, continuous enhancements, and extensive training on a diverse dataset that includes various text sources such as books, articles, websites, and online forums [ 63 ], have contributed to a more engaging and satisfying user experience [ 62 ]. These factors collectively explain its remarkable global growth and set it apart from predecessors like Bard, Bing Chat, ERNIE, and others.
In this context, several studies have explored the technological advancements of chatbots. One noteworthy recent research effort, conducted by SchĂśbel et al. [ 70 ], stands out for its comprehensive analysis of more than 5,000 studies on communication agents. This study offered a comprehensive overview of the historical progression and future prospects of communication agents, including ChatGPT. Moreover, other studies have focused on making comparisons, particularly between ChatGPT and alternative chatbots like Bard, Bing Chat, ERNIE, LaMDA, BlenderBot, and various others. For example, OâLeary [ 53 ] compared two chatbots, LaMDA and BlenderBot, with ChatGPT and revealed that ChatGPT outperformed both. This superiority arises from ChatGPTâs capacity to handle a wider range of questions and generate slightly varied perspectives within specific contexts. Similarly, ChatGPT exhibited an impressive ability to formulate interpretable responses that were easily understood when compared with Google's feature snippet [ 34 ]. Additionally, ChatGPT was compared to other LLMs-based chatbots, including Bard and BERT, as well as ERNIE. The findings indicated that ChatGPT exhibited strong performance in the given tasks, often outperforming the other models [ 59 ].
Furthermore, in the education context, a comprehensive study systematically compared a range of the most promising chatbots, including Bard, Bing Chat, ChatGPT, and Ernie across a multidisciplinary test that required higher-order thinking. The study revealed that ChatGPT achieved the highest score, surpassing Bing Chat and Bard [ 64 ]. Similarly, a comparative analysis was conducted to compare ChatGPT with Bard in answering a set of 30 mathematical questions and logic problems, grouped into two question sets. Set (A) is unavailable online, while Set (B) is available online. The results revealed ChatGPT's superiority in Set (A) over Bard. Nevertheless, Bard's advantage emerged in Set (B) due to its capacity to access the internet directly and retrieve answers, a capability that ChatGPT does not possess [ 57 ]. However, through these varied assessments, ChatGPT consistently highlights its exceptional prowess compared to various alternatives in the ever-evolving chatbot technology.
The widespread adoption of chatbots, especially ChatGPT, by millions of students and educators, has sparked extensive discussions regarding its incorporation into the education sector [ 64 ]. Accordingly, many scholars have contributed to the discourse, expressing both optimism and pessimism regarding the incorporation of ChatGPT into education. For example, ChatGPT has been highlighted for its capabilities in enriching the learning and teaching experience through its ability to support different learning approaches, including adaptive learning, personalized learning, and self-directed learning [ 58 , 60 , 91 ]), deliver summative and formative feedback to students and provide real-time responses to questions, increase the accessibility of information [ 22 , 40 , 43 ], foster studentsâ performance, engagement and motivation [ 14 , 44 , 58 ], and enhance teaching practices [ 17 , 18 , 64 , 74 ].
On the other hand, concerns have been also raised regarding its potential negative effects on learning and teaching. These include the dissemination of false information and references [ 12 , 23 , 61 , 85 ], biased reinforcement [ 47 , 50 ], compromised academic integrity [ 18 , 40 , 66 , 74 ], and the potential decline in students' skills [ 43 , 61 , 64 , 74 ]. As a result, ChatGPT has been banned in multiple countries, including Russia, China, Venezuela, Belarus, and Iran, as well as in various educational institutions in India, Italy, Western Australia, France, and the United States [ 52 , 90 ].
Clearly, the advent of chatbots, especially ChatGPT, has provoked significant controversy due to their potential impact on learning and teaching. This indicates the necessity for further exploration to gain a deeper understanding of this technology and carefully evaluate its potential benefits, limitations, challenges, and threats to education [ 79 ]. Therefore, conducting a systematic literature review will provide valuable insights into the potential prospects and obstacles linked to its incorporation into education. This systematic literature review will primarily focus on ChatGPT, driven by the aforementioned key factors outlined above.
However, the existing literature lacks a systematic literature review of empirical studies. Thus, this systematic literature review aims to address this gap by synthesizing the existing empirical studies conducted on chatbots, particularly ChatGPT, in the field of education, highlighting how ChatGPT has been utilized in educational settings, and identifying any existing gaps. This review may be particularly useful for researchers in the field and educators who are contemplating the integration of ChatGPT or any chatbot into education. The following research questions will guide this study:
What are students' and teachers' initial attempts at utilizing ChatGPT in education?
What are the main findings derived from empirical studies that have incorporated ChatGPT into learning and teaching?
2 Methodology
To conduct this study, the authors followed the essential steps of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) and Okoliâs [ 54 ] steps for conducting a systematic review. These included identifying the studyâs purpose, drafting a protocol, applying a practical screening process, searching the literature, extracting relevant data, evaluating the quality of the included studies, synthesizing the studies, and ultimately writing the review. The subsequent section provides an extensive explanation of how these steps were carried out in this study.
2.1 Identify the purpose
Given the widespread adoption of ChatGPT by students and teachers for various educational purposes, often without a thorough understanding of responsible and effective use or a clear recognition of its potential impact on learning and teaching, the authors recognized the need for further exploration of ChatGPT's impact on education in this early stage. Therefore, they have chosen to conduct a systematic literature review of existing empirical studies that incorporate ChatGPT into educational settings. Despite the limited number of empirical studies due to the novelty of the topic, their goal is to gain a deeper understanding of this technology and proactively evaluate its potential benefits, limitations, challenges, and threats to education. This effort could help to understand initial reactions and attempts at incorporating ChatGPT into education and bring out insights and considerations that can inform the future development of education.
2.2 Draft the protocol
The next step is formulating the protocol. This protocol serves to outline the study process in a rigorous and transparent manner, mitigating researcher bias in study selection and data extraction [ 88 ]. The protocol will include the following steps: generating the research question, predefining a literature search strategy, identifying search locations, establishing selection criteria, assessing the studies, developing a data extraction strategy, and creating a timeline.
2.3 Apply practical screen
The screening step aims to accurately filter the articles resulting from the searching step and select the empirical studies that have incorporated ChatGPT into educational contexts, which will guide us in answering the research questions and achieving the objectives of this study. To ensure the rigorous execution of this step, our inclusion and exclusion criteria were determined based on the authors' experience and informed by previous successful systematic reviews [ 21 ]. Table 1 summarizes the inclusion and exclusion criteria for study selection.
2.4 Literature search
We conducted a thorough literature search to identify articles that explored, examined, and addressed the use of ChatGPT in Educational contexts. We utilized two research databases: Dimensions.ai, which provides access to a large number of research publications, and lens.org, which offers access to over 300 million articles, patents, and other research outputs from diverse sources. Additionally, we included three databases, Scopus, Web of Knowledge, and ERIC, which contain relevant research on the topic that addresses our research questions. To browse and identify relevant articles, we used the following search formula: ("ChatGPT" AND "Education"), which included the Boolean operator "AND" to get more specific results. The subject area in the Scopus and ERIC databases were narrowed to "ChatGPT" and "Education" keywords, and in the WoS database was limited to the "Education" category. The search was conducted between the 3rd and 10th of April 2023, which resulted in 276 articles from all selected databases (111 articles from Dimensions.ai, 65 from Scopus, 28 from Web of Science, 14 from ERIC, and 58 from Lens.org). These articles were imported into the Rayyan web-based system for analysis. The duplicates were identified automatically by the system. Subsequently, the first author manually reviewed the duplicated articles ensured that they had the same content, and then removed them, leaving us with 135 unique articles. Afterward, the titles, abstracts, and keywords of the first 40 manuscripts were scanned and reviewed by the first author and were discussed with the second and third authors to resolve any disagreements. Subsequently, the first author proceeded with the filtering process for all articles and carefully applied the inclusion and exclusion criteria as presented in Table 1 . Articles that met any one of the exclusion criteria were eliminated, resulting in 26 articles. Afterward, the authors met to carefully scan and discuss them. The authors agreed to eliminate any empirical studies solely focused on checking ChatGPT capabilities, as these studies do not guide us in addressing the research questions and achieving the study's objectives. This resulted in 14 articles eligible for analysis.
2.5 Quality appraisal
The examination and evaluation of the quality of the extracted articles is a vital step [ 9 ]. Therefore, the extracted articles were carefully evaluated for quality using Finkâs [ 24 ] standards, which emphasize the necessity for detailed descriptions of methodology, results, conclusions, strengths, and limitations. The process began with a thorough assessment of each study's design, data collection, and analysis methods to ensure their appropriateness and comprehensive execution. The clarity, consistency, and logical progression from data to results and conclusions were also critically examined. Potential biases and recognized limitations within the studies were also scrutinized. Ultimately, two articles were excluded for failing to meet Finkâs criteria, particularly in providing sufficient detail on methodology, results, conclusions, strengths, or limitations. The review process is illustrated in Fig. 1 .
![lit 21 reviews figure 1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig1_HTML.png)
The study selection process
2.6 Data extraction
The next step is data extraction, the process of capturing the key information and categories from the included studies. To improve efficiency, reduce variation among authors, and minimize errors in data analysis, the coding categories were constructed using Creswell's [ 15 ] coding techniques for data extraction and interpretation. The coding process involves three sequential steps. The initial stage encompasses open coding , where the researcher examines the data, generates codes to describe and categorize it, and gains a deeper understanding without preconceived ideas. Following open coding is axial coding , where the interrelationships between codes from open coding are analyzed to establish more comprehensive categories or themes. The process concludes with selective coding , refining and integrating categories or themes to identify core concepts emerging from the data. The first coder performed the coding process, then engaged in discussions with the second and third authors to finalize the coding categories for the first five articles. The first coder then proceeded to code all studies and engaged again in discussions with the other authors to ensure the finalization of the coding process. After a comprehensive analysis and capturing of the key information from the included studies, the data extraction and interpretation process yielded several themes. These themes have been categorized and are presented in Table 2 . It is important to note that open coding results were removed from Table 2 for aesthetic reasons, as it included many generic aspects, such as words, short phrases, or sentences mentioned in the studies.
2.7 Synthesize studies
In this stage, we will gather, discuss, and analyze the key findings that emerged from the selected studies. The synthesis stage is considered a transition from an author-centric to a concept-centric focus, enabling us to map all the provided information to achieve the most effective evaluation of the data [ 87 ]. Initially, the authors extracted data that included general information about the selected studies, including the author(s)' names, study titles, years of publication, educational levels, research methodologies, sample sizes, participants, main aims or objectives, raw data sources, and analysis methods. Following that, all key information and significant results from the selected studies were compiled using Creswellâs [ 15 ] coding techniques for data extraction and interpretation to identify core concepts and themes emerging from the data, focusing on those that directly contributed to our research questions and objectives, such as the initial utilization of ChatGPT in learning and teaching, learners' and educators' familiarity with ChatGPT, and the main findings of each study. Finally, the data related to each selected study were extracted into an Excel spreadsheet for data processing. The Excel spreadsheet was reviewed by the authors, including a series of discussions to ensure the finalization of this process and prepare it for further analysis. Afterward, the final result being analyzed and presented in various types of charts and graphs. Table 4 presents the extracted data from the selected studies, with each study labeled with a capital 'S' followed by a number.
This section consists of two main parts. The first part provides a descriptive analysis of the data compiled from the reviewed studies. The second part presents the answers to the research questions and the main findings of these studies.
3.1 Part 1: descriptive analysis
This section will provide a descriptive analysis of the reviewed studies, including educational levels and fields, participants distribution, country contribution, research methodologies, study sample size, study population, publication year, list of journals, familiarity with ChatGPT, source of data, and the main aims and objectives of the studies. Table 4 presents a comprehensive overview of the extracted data from the selected studies.
3.1.1 The number of the reviewed studies and publication years
The total number of the reviewed studies was 14. All studies were empirical studies and published in different journals focusing on Education and Technology. One study was published in 2022 [S1], while the remaining were published in 2023 [S2]-[S14]. Table 3 illustrates the year of publication, the names of the journals, and the number of reviewed studies published in each journal for the studies reviewed.
3.1.2 Educational levels and fields
The majority of the reviewed studies, 11 studies, were conducted in higher education institutions [S1]-[S10] and [S13]. Two studies did not specify the educational level of the population [S12] and [S14], while one study focused on elementary education [S11]. However, the reviewed studies covered various fields of education. Three studies focused on Arts and Humanities Education [S8], [S11], and [S14], specifically English Education. Two studies focused on Engineering Education, with one in Computer Engineering [S2] and the other in Construction Education [S3]. Two studies focused on Mathematics Education [S5] and [S12]. One study focused on Social Science Education [S13]. One study focused on Early Education [S4]. One study focused on Journalism Education [S9]. Finally, three studies did not specify the field of education [S1], [S6], and [S7]. Figure 2 represents the educational levels in the reviewed studies, while Fig. 3 represents the context of the reviewed studies.
![lit 21 reviews figure 2](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig2_HTML.png)
Educational levels in the reviewed studies
![lit 21 reviews figure 3](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig3_HTML.png)
Context of the reviewed studies
3.1.3 Participants distribution and countries contribution
The reviewed studies have been conducted across different geographic regions, providing a diverse representation of the studies. The majority of the studies, 10 in total, [S1]-[S3], [S5]-[S9], [S11], and [S14], primarily focused on participants from single countries such as Pakistan, the United Arab Emirates, China, Indonesia, Poland, Saudi Arabia, South Korea, Spain, Tajikistan, and the United States. In contrast, four studies, [S4], [S10], [S12], and [S13], involved participants from multiple countries, including China and the United States [S4], China, the United Kingdom, and the United States [S10], the United Arab Emirates, Oman, Saudi Arabia, and Jordan [S12], Turkey, Sweden, Canada, and Australia [ 13 ]. Figures 4 and 5 illustrate the distribution of participants, whether from single or multiple countries, and the contribution of each country in the reviewed studies, respectively.
![lit 21 reviews figure 4](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig4_HTML.png)
The reviewed studies conducted in single or multiple countries
![lit 21 reviews figure 5](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig5_HTML.png)
The Contribution of each country in the studies
3.1.4 Study population and sample size
Four study populations were included: university students, university teachers, university teachers and students, and elementary school teachers. Six studies involved university students [S2], [S3], [S5] and [S6]-[S8]. Three studies focused on university teachers [S1], [S4], and [S6], while one study specifically targeted elementary school teachers [S11]. Additionally, four studies included both university teachers and students [S10] and [ 12 , 13 , 14 ], and among them, study [S13] specifically included postgraduate students. In terms of the sample size of the reviewed studies, nine studies included a small sample size of less than 50 participants [S1], [S3], [S6], [S8], and [S10]-[S13]. Three studies had 50â100 participants [S2], [S9], and [S14]. Only one study had more than 100 participants [S7]. It is worth mentioning that study [S4] adopted a mixed methods approach, including 10 participants for qualitative analysis and 110 participants for quantitative analysis.
3.1.5 Participantsâ familiarity with using ChatGPT
The reviewed studies recruited a diverse range of participants with varying levels of familiarity with ChatGPT. Five studies [S2], [S4], [S6], [S8], and [S12] involved participants already familiar with ChatGPT, while eight studies [S1], [S3], [S5], [S7], [S9], [S10], [S13] and [S14] included individuals with differing levels of familiarity. Notably, one study [S11] had participants who were entirely unfamiliar with ChatGPT. It is important to note that four studies [S3], [S5], [S9], and [S11] provided training or guidance to their participants before conducting their studies, while ten studies [S1], [S2], [S4], [S6]-[S8], [S10], and [S12]-[S14] did not provide training due to the participants' existing familiarity with ChatGPT.
3.1.6 Research methodology approaches and source(S) of data
The reviewed studies adopted various research methodology approaches. Seven studies adopted qualitative research methodology [S1], [S4], [S6], [S8], [S10], [S11], and [S12], while three studies adopted quantitative research methodology [S3], [S7], and [S14], and four studies employed mixed-methods, which involved a combination of both the strengths of qualitative and quantitative methods [S2], [S5], [S9], and [S13].
In terms of the source(s) of data, the reviewed studies obtained their data from various sources, such as interviews, questionnaires, and pre-and post-tests. Six studies relied on interviews as their primary source of data collection [S1], [S4], [S6], [S10], [S11], and [S12], four studies relied on questionnaires [S2], [S7], [S13], and [S14], two studies combined the use of pre-and post-tests and questionnaires for data collection [S3] and [S9], while two studies combined the use of questionnaires and interviews to obtain the data [S5] and [S8]. It is important to note that six of the reviewed studies were quasi-experimental [S3], [S5], [S8], [S9], [S12], and [S14], while the remaining ones were experimental studies [S1], [S2], [S4], [S6], [S7], [S10], [S11], and [S13]. Figures 6 and 7 illustrate the research methodologies and the source (s) of data used in the reviewed studies, respectively.
![lit 21 reviews figure 6](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig6_HTML.png)
Research methodologies in the reviewed studies
![lit 21 reviews figure 7](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig7_HTML.png)
Source of data in the reviewed studies
3.1.7 The aim and objectives of the studies
The reviewed studies encompassed a diverse set of aims, with several of them incorporating multiple primary objectives. Six studies [S3], [S6], [S7], [S8], [S11], and [S12] examined the integration of ChatGPT in educational contexts, and four studies [S4], [S5], [S13], and [S14] investigated the various implications of its use in education, while three studies [S2], [S9], and [S10] aimed to explore both its integration and implications in education. Additionally, seven studies explicitly explored attitudes and perceptions of students [S2] and [S3], educators [S1] and [S6], or both [S10], [S12], and [S13] regarding the utilization of ChatGPT in educational settings.
3.2 Part 2: research questions and main findings of the reviewed studies
This part will present the answers to the research questions and the main findings of the reviewed studies, classified into two main categories (learning and teaching) according to AI Education classification by [ 36 ]. Figure 8 summarizes the main findings of the reviewed studies in a visually informative diagram. Table 4 provides a detailed list of the key information extracted from the selected studies that led to generating these themes.
![lit 21 reviews figure 8](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs44217-024-00138-2/MediaObjects/44217_2024_138_Fig8_HTML.png)
The main findings in the reviewed studies
4 Students' initial attempts at utilizing ChatGPT in learning and main findings from students' perspective
4.1 virtual intelligent assistant.
Nine studies demonstrated that ChatGPT has been utilized by students as an intelligent assistant to enhance and support their learning. Students employed it for various purposes, such as answering on-demand questions [S2]-[S5], [S8], [S10], and [S12], providing valuable information and learning resources [S2]-[S5], [S6], and [S8], as well as receiving immediate feedback [S2], [S4], [S9], [S10], and [S12]. In this regard, students generally were confident in the accuracy of ChatGPT's responses, considering them relevant, reliable, and detailed [S3], [S4], [S5], and [S8]. However, some students indicated the need for improvement, as they found that answers are not always accurate [S2], and that misleading information may have been provided or that it may not always align with their expectations [S6] and [S10]. It was also observed by the students that the accuracy of ChatGPT is dependent on several factors, including the quality and specificity of the user's input, the complexity of the question or topic, and the scope and relevance of its training data [S12]. Many students felt that ChatGPT's answers were not always accurate and most of them believed that it requires good background knowledge to work with.
4.2 Writing and language proficiency assistant
Six of the reviewed studies highlighted that ChatGPT has been utilized by students as a valuable assistant tool to improve their academic writing skills and language proficiency. Among these studies, three mainly focused on English education, demonstrating that students showed sufficient mastery in using ChatGPT for generating ideas, summarizing, paraphrasing texts, and completing writing essays [S8], [S11], and [S14]. Furthermore, ChatGPT helped them in writing by making students active investigators rather than passive knowledge recipients and facilitated the development of their writing skills [S11] and [S14]. Similarly, ChatGPT allowed students to generate unique ideas and perspectives, leading to deeper analysis and reflection on their journalism writing [S9]. In terms of language proficiency, ChatGPT allowed participants to translate content into their home languages, making it more accessible and relevant to their context [S4]. It also enabled them to request changes in linguistic tones or flavors [S8]. Moreover, participants used it to check grammar or as a dictionary [S11].
4.3 Valuable resource for learning approaches
Five studies demonstrated that students used ChatGPT as a valuable complementary resource for self-directed learning. It provided learning resources and guidance on diverse educational topics and created a supportive home learning environment [S2] and [S4]. Moreover, it offered step-by-step guidance to grasp concepts at their own pace and enhance their understanding [S5], streamlined task and project completion carried out independently [S7], provided comprehensive and easy-to-understand explanations on various subjects [S10], and assisted in studying geometry operations, thereby empowering them to explore geometry operations at their own pace [S12]. Three studies showed that students used ChatGPT as a valuable learning resource for personalized learning. It delivered age-appropriate conversations and tailored teaching based on a child's interests [S4], acted as a personalized learning assistant, adapted to their needs and pace, which assisted them in understanding mathematical concepts [S12], and enabled personalized learning experiences in social sciences by adapting to students' needs and learning styles [S13]. On the other hand, it is important to note that, according to one study [S5], students suggested that using ChatGPT may negatively affect collaborative learning competencies between students.
4.4 Enhancing students' competencies
Six of the reviewed studies have shown that ChatGPT is a valuable tool for improving a wide range of skills among students. Two studies have provided evidence that ChatGPT led to improvements in students' critical thinking, reasoning skills, and hazard recognition competencies through engaging them in interactive conversations or activities and providing responses related to their disciplines in journalism [S5] and construction education [S9]. Furthermore, two studies focused on mathematical education have shown the positive impact of ChatGPT on students' problem-solving abilities in unraveling problem-solving questions [S12] and enhancing the students' understanding of the problem-solving process [S5]. Lastly, one study indicated that ChatGPT effectively contributed to the enhancement of conversational social skills [S4].
4.5 Supporting students' academic success
Seven of the reviewed studies highlighted that students found ChatGPT to be beneficial for learning as it enhanced learning efficiency and improved the learning experience. It has been observed to improve students' efficiency in computer engineering studies by providing well-structured responses and good explanations [S2]. Additionally, students found it extremely useful for hazard reporting [S3], and it also enhanced their efficiency in solving mathematics problems and capabilities [S5] and [S12]. Furthermore, by finding information, generating ideas, translating texts, and providing alternative questions, ChatGPT aided students in deepening their understanding of various subjects [S6]. It contributed to an increase in students' overall productivity [S7] and improved efficiency in composing written tasks [S8]. Regarding learning experiences, ChatGPT was instrumental in assisting students in identifying hazards that they might have otherwise overlooked [S3]. It also improved students' learning experiences in solving mathematics problems and developing abilities [S5] and [S12]. Moreover, it increased students' successful completion of important tasks in their studies [S7], particularly those involving average difficulty writing tasks [S8]. Additionally, ChatGPT increased the chances of educational success by providing students with baseline knowledge on various topics [S10].
5 Teachers' initial attempts at utilizing ChatGPT in teaching and main findings from teachers' perspective
5.1 valuable resource for teaching.
The reviewed studies showed that teachers have employed ChatGPT to recommend, modify, and generate diverse, creative, organized, and engaging educational contents, teaching materials, and testing resources more rapidly [S4], [S6], [S10] and [S11]. Additionally, teachers experienced increased productivity as ChatGPT facilitated quick and accurate responses to questions, fact-checking, and information searches [S1]. It also proved valuable in constructing new knowledge [S6] and providing timely answers to students' questions in classrooms [S11]. Moreover, ChatGPT enhanced teachers' efficiency by generating new ideas for activities and preplanning activities for their students [S4] and [S6], including interactive language game partners [S11].
5.2 Improving productivity and efficiency
The reviewed studies showed that participants' productivity and work efficiency have been significantly enhanced by using ChatGPT as it enabled them to allocate more time to other tasks and reduce their overall workloads [S6], [S10], [S11], [S13], and [S14]. However, three studies [S1], [S4], and [S11], indicated a negative perception and attitude among teachers toward using ChatGPT. This negativity stemmed from a lack of necessary skills to use it effectively [S1], a limited familiarity with it [S4], and occasional inaccuracies in the content provided by it [S10].
5.3 Catalyzing new teaching methodologies
Five of the reviewed studies highlighted that educators found the necessity of redefining their teaching profession with the assistance of ChatGPT [S11], developing new effective learning strategies [S4], and adapting teaching strategies and methodologies to ensure the development of essential skills for future engineers [S5]. They also emphasized the importance of adopting new educational philosophies and approaches that can evolve with the introduction of ChatGPT into the classroom [S12]. Furthermore, updating curricula to focus on improving human-specific features, such as emotional intelligence, creativity, and philosophical perspectives [S13], was found to be essential.
5.4 Effective utilization of CHATGPT in teaching
According to the reviewed studies, effective utilization of ChatGPT in education requires providing teachers with well-structured training, support, and adequate background on how to use ChatGPT responsibly [S1], [S3], [S11], and [S12]. Establishing clear rules and regulations regarding its usage is essential to ensure it positively impacts the teaching and learning processes, including students' skills [S1], [S4], [S5], [S8], [S9], and [S11]-[S14]. Moreover, conducting further research and engaging in discussions with policymakers and stakeholders is indeed crucial for the successful integration of ChatGPT in education and to maximize the benefits for both educators and students [S1], [S6]-[S10], and [S12]-[S14].
6 Discussion
The purpose of this review is to conduct a systematic review of empirical studies that have explored the utilization of ChatGPT, one of todayâs most advanced LLM-based chatbots, in education. The findings of the reviewed studies showed several ways of ChatGPT utilization in different learning and teaching practices as well as it provided insights and considerations that can facilitate its effective and responsible use in future educational contexts. The results of the reviewed studies came from diverse fields of education, which helped us avoid a biased review that is limited to a specific field. Similarly, the reviewed studies have been conducted across different geographic regions. This kind of variety in geographic representation enriched the findings of this review.
In response to RQ1 , "What are students' and teachers' initial attempts at utilizing ChatGPT in education?", the findings from this review provide comprehensive insights. Chatbots, including ChatGPT, play a crucial role in supporting student learning, enhancing their learning experiences, and facilitating diverse learning approaches [ 42 , 43 ]. This review found that this tool, ChatGPT, has been instrumental in enhancing students' learning experiences by serving as a virtual intelligent assistant, providing immediate feedback, on-demand answers, and engaging in educational conversations. Additionally, students have benefited from ChatGPTâs ability to generate ideas, compose essays, and perform tasks like summarizing, translating, paraphrasing texts, or checking grammar, thereby enhancing their writing and language competencies. Furthermore, students have turned to ChatGPT for assistance in understanding concepts and homework, providing structured learning plans, and clarifying assignments and tasks, which fosters a supportive home learning environment, allowing them to take responsibility for their own learning and cultivate the skills and approaches essential for supportive home learning environment [ 26 , 27 , 28 ]. This finding aligns with the study of Saqr et al. [ 68 , 69 ] who highlighted that, when students actively engage in their own learning process, it yields additional advantages, such as heightened motivation, enhanced achievement, and the cultivation of enthusiasm, turning them into advocates for their own learning.
Moreover, students have utilized ChatGPT for tailored teaching and step-by-step guidance on diverse educational topics, streamlining task and project completion, and generating and recommending educational content. This personalization enhances the learning environment, leading to increased academic success. This finding aligns with other recent studies [ 26 , 27 , 28 , 60 , 66 ] which revealed that ChatGPT has the potential to offer personalized learning experiences and support an effective learning process by providing students with customized feedback and explanations tailored to their needs and abilities. Ultimately, fostering students' performance, engagement, and motivation, leading to increase students' academic success [ 14 , 44 , 58 ]. This ultimate outcome is in line with the findings of Saqr et al. [ 68 , 69 ], which emphasized that learning strategies are important catalysts of students' learning, as students who utilize effective learning strategies are more likely to have better academic achievement.
Teachers, too, have capitalized on ChatGPT's capabilities to enhance productivity and efficiency, using it for creating lesson plans, generating quizzes, providing additional resources, generating and preplanning new ideas for activities, and aiding in answering studentsâ questions. This adoption of technology introduces new opportunities to support teaching and learning practices, enhancing teacher productivity. This finding aligns with those of Day [ 17 ], De Castro [ 18 ], and Su and Yang [ 74 ] as well as with those of Valtonen et al. [ 82 ], who revealed that emerging technological advancements have opened up novel opportunities and means to support teaching and learning practices, and enhance teachersâ productivity.
In response to RQ2 , "What are the main findings derived from empirical studies that have incorporated ChatGPT into learning and teaching?", the findings from this review provide profound insights and raise significant concerns. Starting with the insights, chatbots, including ChatGPT, have demonstrated the potential to reshape and revolutionize education, creating new, novel opportunities for enhancing the learning process and outcomes [ 83 ], facilitating different learning approaches, and offering a range of pedagogical benefits [ 19 , 43 , 72 ]. In this context, this review found that ChatGPT could open avenues for educators to adopt or develop new effective learning and teaching strategies that can evolve with the introduction of ChatGPT into the classroom. Nonetheless, there is an evident lack of research understanding regarding the potential impact of generative machine learning models within diverse educational settings [ 83 ]. This necessitates teachers to attain a high level of proficiency in incorporating chatbots, such as ChatGPT, into their classrooms to create inventive, well-structured, and captivating learning strategies. In the same vein, the review also found that teachers without the requisite skills to utilize ChatGPT realized that it did not contribute positively to their work and could potentially have adverse effects [ 37 ]. This concern could lead to inequity of access to the benefits of chatbots, including ChatGPT, as individuals who lack the necessary expertise may not be able to harness their full potential, resulting in disparities in educational outcomes and opportunities. Therefore, immediate action is needed to address these potential issues. A potential solution is offering training, support, and competency development for teachers to ensure that all of them can leverage chatbots, including ChatGPT, effectively and equitably in their educational practices [ 5 , 28 , 80 ], which could enhance accessibility and inclusivity, and potentially result in innovative outcomes [ 82 , 83 ].
Additionally, chatbots, including ChatGPT, have the potential to significantly impact students' thinking abilities, including retention, reasoning, analysis skills [ 19 , 45 ], and foster innovation and creativity capabilities [ 83 ]. This review found that ChatGPT could contribute to improving a wide range of skills among students. However, it found that frequent use of ChatGPT may result in a decrease in innovative capacities, collaborative skills and cognitive capacities, and students' motivation to attend classes, as well as could lead to reduced higher-order thinking skills among students [ 22 , 29 ]. Therefore, immediate action is needed to carefully examine the long-term impact of chatbots such as ChatGPT, on learning outcomes as well as to explore its incorporation into educational settings as a supportive tool without compromising students' cognitive development and critical thinking abilities. In the same vein, the review also found that it is challenging to draw a consistent conclusion regarding the potential of ChatGPT to aid self-directed learning approach. This finding aligns with the recent study of Baskara [ 8 ]. Therefore, further research is needed to explore the potential of ChatGPT for self-directed learning. One potential solution involves utilizing learning analytics as a novel approach to examine various aspects of students' learning and support them in their individual endeavors [ 32 ]. This approach can bridge this gap by facilitating an in-depth analysis of how learners engage with ChatGPT, identifying trends in self-directed learning behavior, and assessing its influence on their outcomes.
Turning to the significant concerns, on the other hand, a fundamental challenge with LLM-based chatbots, including ChatGPT, is the accuracy and quality of the provided information and responses, as they provide false information as truthâa phenomenon often referred to as "hallucination" [ 3 , 49 ]. In this context, this review found that the provided information was not entirely satisfactory. Consequently, the utilization of chatbots presents potential concerns, such as generating and providing inaccurate or misleading information, especially for students who utilize it to support their learning. This finding aligns with other findings [ 6 , 30 , 35 , 40 ] which revealed that incorporating chatbots such as ChatGPT, into education presents challenges related to its accuracy and reliability due to its training on a large corpus of data, which may contain inaccuracies and the way users formulate or ask ChatGPT. Therefore, immediate action is needed to address these potential issues. One possible solution is to equip students with the necessary skills and competencies, which include a background understanding of how to use it effectively and the ability to assess and evaluate the information it generates, as the accuracy and the quality of the provided information depend on the input, its complexity, the topic, and the relevance of its training data [ 28 , 49 , 86 ]. However, it's also essential to examine how learners can be educated about how these models operate, the data used in their training, and how to recognize their limitations, challenges, and issues [ 79 ].
Furthermore, chatbots present a substantial challenge concerning maintaining academic integrity [ 20 , 56 ] and copyright violations [ 83 ], which are significant concerns in education. The review found that the potential misuse of ChatGPT might foster cheating, facilitate plagiarism, and threaten academic integrity. This issue is also affirmed by the research conducted by Basic et al. [ 7 ], who presented evidence that students who utilized ChatGPT in their writing assignments had more plagiarism cases than those who did not. These findings align with the conclusions drawn by Cotton et al. [ 13 ], Hisan and Amri [ 33 ] and Sullivan et al. [ 75 ], who revealed that the integration of chatbots such as ChatGPT into education poses a significant challenge to the preservation of academic integrity. Moreover, chatbots, including ChatGPT, have increased the difficulty in identifying plagiarism [ 47 , 67 , 76 ]. The findings from previous studies [ 1 , 84 ] indicate that AI-generated text often went undetected by plagiarism software, such as Turnitin. However, Turnitin and other similar plagiarism detection tools, such as ZeroGPT, GPTZero, and Copyleaks, have since evolved, incorporating enhanced techniques to detect AI-generated text, despite the possibility of false positives, as noted in different studies that have found these tools still not yet fully ready to accurately and reliably identify AI-generated text [ 10 , 51 ], and new novel detection methods may need to be created and implemented for AI-generated text detection [ 4 ]. This potential issue could lead to another concern, which is the difficulty of accurately evaluating student performance when they utilize chatbots such as ChatGPT assistance in their assignments. Consequently, the most LLM-driven chatbots present a substantial challenge to traditional assessments [ 64 ]. The findings from previous studies indicate the importance of rethinking, improving, and redesigning innovative assessment methods in the era of chatbots [ 14 , 20 , 64 , 75 ]. These methods should prioritize the process of evaluating students' ability to apply knowledge to complex cases and demonstrate comprehension, rather than solely focusing on the final product for assessment. Therefore, immediate action is needed to address these potential issues. One possible solution would be the development of clear guidelines, regulatory policies, and pedagogical guidance. These measures would help regulate the proper and ethical utilization of chatbots, such as ChatGPT, and must be established before their introduction to students [ 35 , 38 , 39 , 41 , 89 ].
In summary, our review has delved into the utilization of ChatGPT, a prominent example of chatbots, in education, addressing the question of how ChatGPT has been utilized in education. However, there remain significant gaps, which necessitate further research to shed light on this area.
7 Conclusions
This systematic review has shed light on the varied initial attempts at incorporating ChatGPT into education by both learners and educators, while also offering insights and considerations that can facilitate its effective and responsible use in future educational contexts. From the analysis of 14 selected studies, the review revealed the dual-edged impact of ChatGPT in educational settings. On the positive side, ChatGPT significantly aided the learning process in various ways. Learners have used it as a virtual intelligent assistant, benefiting from its ability to provide immediate feedback, on-demand answers, and easy access to educational resources. Additionally, it was clear that learners have used it to enhance their writing and language skills, engaging in practices such as generating ideas, composing essays, and performing tasks like summarizing, translating, paraphrasing texts, or checking grammar. Importantly, other learners have utilized it in supporting and facilitating their directed and personalized learning on a broad range of educational topics, assisting in understanding concepts and homework, providing structured learning plans, and clarifying assignments and tasks. Educators, on the other hand, found ChatGPT beneficial for enhancing productivity and efficiency. They used it for creating lesson plans, generating quizzes, providing additional resources, and answers learners' questions, which saved time and allowed for more dynamic and engaging teaching strategies and methodologies.
However, the review also pointed out negative impacts. The results revealed that overuse of ChatGPT could decrease innovative capacities and collaborative learning among learners. Specifically, relying too much on ChatGPT for quick answers can inhibit learners' critical thinking and problem-solving skills. Learners might not engage deeply with the material or consider multiple solutions to a problem. This tendency was particularly evident in group projects, where learners preferred consulting ChatGPT individually for solutions over brainstorming and collaborating with peers, which negatively affected their teamwork abilities. On a broader level, integrating ChatGPT into education has also raised several concerns, including the potential for providing inaccurate or misleading information, issues of inequity in access, challenges related to academic integrity, and the possibility of misusing the technology.
Accordingly, this review emphasizes the urgency of developing clear rules, policies, and regulations to ensure ChatGPT's effective and responsible use in educational settings, alongside other chatbots, by both learners and educators. This requires providing well-structured training to educate them on responsible usage and understanding its limitations, along with offering sufficient background information. Moreover, it highlights the importance of rethinking, improving, and redesigning innovative teaching and assessment methods in the era of ChatGPT. Furthermore, conducting further research and engaging in discussions with policymakers and stakeholders are essential steps to maximize the benefits for both educators and learners and ensure academic integrity.
It is important to acknowledge that this review has certain limitations. Firstly, the limited inclusion of reviewed studies can be attributed to several reasons, including the novelty of the technology, as new technologies often face initial skepticism and cautious adoption; the lack of clear guidelines or best practices for leveraging this technology for educational purposes; and institutional or governmental policies affecting the utilization of this technology in educational contexts. These factors, in turn, have affected the number of studies available for review. Secondly, the utilization of the original version of ChatGPT, based on GPT-3 or GPT-3.5, implies that new studies utilizing the updated version, GPT-4 may lead to different findings. Therefore, conducting follow-up systematic reviews is essential once more empirical studies on ChatGPT are published. Additionally, long-term studies are necessary to thoroughly examine and assess the impact of ChatGPT on various educational practices.
Despite these limitations, this systematic review has highlighted the transformative potential of ChatGPT in education, revealing its diverse utilization by learners and educators alike and summarized the benefits of incorporating it into education, as well as the forefront critical concerns and challenges that must be addressed to facilitate its effective and responsible use in future educational contexts. This review could serve as an insightful resource for practitioners who seek to integrate ChatGPT into education and stimulate further research in the field.
Data availability
The data supporting our findings are available upon request.
Abbreviations
- Artificial intelligence
AI in education
Large language model
Artificial neural networks
Chat Generative Pre-Trained Transformer
Recurrent neural networks
Long short-term memory
Reinforcement learning from human feedback
Natural language processing
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
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The process of synthesizing the data presented in Table 4 involved identifying the relevant studies through a search process of databases (ERIC, Scopus, Web of Knowledge, Dimensions.ai, and lens.org) using specific keywords "ChatGPT" and "education". Following this, inclusion/exclusion criteria were applied, and data extraction was performed using Creswell's [ 15 ] coding techniques to capture key information and identify common themes across the included studies.
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Albadarin, Y., Saqr, M., Pope, N. et al. A systematic literature review of empirical research on ChatGPT in education. Discov Educ 3 , 60 (2024). https://doi.org/10.1007/s44217-024-00138-2
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Jenny Erpenbeckâs âKairosâ Wins the International Booker Prize
Translated by Michael Hofmann, itâs the first novel originally written in German to win the major literary award.
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Jenny Erpenbeckâs â Kairos ,â a novel about a torrid love affair in the final years of East Germany, won on Tuesday the International Booker Prize, the renowned award for fiction translated into English.
Erpenbeck shares the award of 50,000 British pounds, about $63,500, with Michael Hofmann, who translated the book into English. The pair received the prize during a ceremony at the Tate Modern art museum in London.
After receiving the award, the pair seemed lost for words. Erpenbeck thanked Hofmann, and Hofmann thanked Erpenbeck: âI want to thank Jenny for her trust in me,â he said. âEr, thatâs about the size of it.â
Eleanor Wachtel, the chair of the judges, said in a news conference that âKairosâ was more than a simple evocation of a romance. The âself-absorption of the loversâ â a student and a 50-something novelist â and âtheir descent into a destructive vortexâ tracks the history of East Germany before the collapse of the Berlin Wall, she said.
Like that country, Wachtel added, the coupleâs relationship âstarts with optimism and trust, then unravels so badly.â
âWhat makes âKairosâ so unusual is that itâs both beautiful and uncomfortable, personal and political, psychological and very moving,â Wachtel said. The judging panel deliberated for half an hour before deciding to give âKairosâ the prize, she added.
âKairosâ beat five other shortlisted titles , including Jente Posthumaâs âWhat Iâd Rather Not Think About,â translated from Dutch by Sarah Timmer Harvey, about a woman grieving her twin brother, and Hwang Sok-yongâs âMater 2-10,â translated from Korean by Sora Kim-Russell and Youngjae Josephine Bae, which traces North and South Korean history through a family of railway workers.
After its publication in English last year, some reviewers praised âKairosâ as the latest novel to suggest Erpenbeck could be a future winner of the Nobel Prize in Literature. Dwight Garner, in The New York Times , said that Erpenbeck was âamong the most sophisticated and powerful novelists we have.â âKairos,â he added, was so moving it had âa subterranean force.â
âI donât generally read the books I review twice,â Garner said, âbut this one I did.â
Established in 2005, the International Booker Prize is separate from the Booker Prize, which recognizes fiction written in English. Originally awarded for a writerâs entire body of work, in 2016 the international prize became an annual award for the best novel translated into English. Past winners have included Han Kangâs â The Vegetarian, â translated from Korean by Deborah Smith, and Olga Tokarczukâs â Flights ,â translated from Polish by Jennifer Croft.
Erpenbeck is the first German novelist to win the award, while Hofmann is the first male translator to receive the honor.
Erpenbeck, 57, grew up in Berlin in what was then the German Democratic Republic, or East Germany, and the country has provided either a setting or context for much of her fiction, including 2017âs â Go, Went, Gone â about a professor befriending a group of African refugees in present day Berlin.
In a recent interview with The Times , Erpenbeck said that the tumult around the Berlin Wallâs collapse led to her becoming a writer, as she grappled with what it meant to lose âthe system that I knew, that I grew up in.â
Stories about the fall of the Berlin Wall focus on the idea of freedom, Erpenbeck said in a recent interview for the Booker Prizeâs website , but that was ânot the onlyâ story that could be told.
âKairos,â she added, was âalso about what follows the happy end.â
Alex Marshall is a Times reporter covering European culture. He is based in London. More about Alex Marshall
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Wandering spleen presenting in the form of right sided pelvic mass and pain in a patient with AD-PCKD: a case report and review of the literature
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Wandering spleen is a rare clinical entity in which the spleen is hypermobile and migrate from its normal left hypochondriac position to any other abdominal or pelvic position as a result of absent or abnormal laxity of the suspensory ligaments (Puranik in Gastroenterol Rep 5:241, 2015, Evangelos in Am J Case Rep. 21, 2020) which in turn is due to either congenital laxity or precipitated by trauma, pregnancy, or connective tissue disorder (Puranik in Gastroenterol Rep 5:241, 2015, Jawad in Cureus 15, 2023). It may be asymptomatic and accidentally discovered for imaging done for other reasons or cause symptoms as a result of torsion of its pedicle and infarction or compression on adjacent viscera on its new position. It needs to be surgically treated upon discovery either by splenopexy or splectomy based on whether the spleen is mobile or not.
Case presentation
We present a case of 39Â years old female Ethiopian patient who presented to us complaining constant lower abdominal pain especially on the right side associated with swelling of one year which got worse over the preceding few months of her presentation to our facility. She is primiparous with delivery by C/section and a known case of HIV infection on HAART. Physical examination revealed a right lower quadrant well defined, fairly mobile and slightly tender swelling. Hematologic investigations are unremarkable. Imaging with abdominopelvic U/S and CT-scan showed a predominantly cystic, hypo attenuating right sided pelvic mass with narrow elongated attachment to pancreatic tail and absent spleen in its normal position. CT also showed multiple different sized purely cystic lesions all over both kidneys and the pancreas compatible with AD polycystic kidney and pancreatic disease.
With a diagnosis of wandering possibly infarcted spleen, she underwent laparotomy, the finding being a fully infarcted spleen located on the right half of the upper pelvis with twisted pedicle and dense adhesions to the adjacent distal ileum and colon. Release of adhesions and splenectomy was done. Her post-operative course was uneventful.
Wandering spleen is a rare clinical condition that needs to be included in the list of differential diagnosis in patients presenting with lower abdominal and pelvic masses. As we have learnt from our case, a high index of suspicion is required to detect it early and intervene by doing splenopexy and thereby avoiding splenectomy and its related complications.
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Introduction
Wandering spleen is a rare clinical entity characterized by hypermobility of the spleen as a result of absence or abnormal laxity of its suspensory ligaments which in turn can be congenital or precipitated by a number of risk factors like repeated pregnancy, trauma, surgery or connective tissue disorder. The spleen therefore migrates from its normal left hypochondriac position, to other parts of the peritoneal cavity especially the pelvis [ 3 ]. Since the first case report in 1667, there have been less than 600 cases reported in the literature so far [ 1 , 3 ].
Wandering spleen can have different clinical presentations ranging from asymptomatic incidental finding on imaging to features of acute abdomen as a result of complete torsion of the pedicle and total infarction of the spleen or complete obstruction of adjacent hollow viscus due to pressure effect. Less dramatic presentation includes chronic lower abdominal pain, swelling and symptoms of partial obstruction of bowel especially of the colon [ 3 , 4 , 5 , 6 ].
Diagnosis is confirmed by imaging usually abdominal ultrasound or CT which reveals that the spleen is absent from its normal anatomical position but seen somewhere else in the new location within the peritoneal cavity [ 3 , 9 , 10 ]. Once diagnosed, surgical intervention is required either by splenopexy or splenectomy depending on the viability of the organ [ 3 , 5 ] and can be done laparoscopically or by laparotomy.
Owing to its rarity, a high index of suspicion is required and this condition should always be considered as a possible differential diagnosis in patients presenting with lower abdominal swelling and pain. We present this case to share our experience in diagnosing and managing such a rare pathology and once again bring it to the attention of fellow clinicians handling this sort of abdominal conditions.
Case summary
Our patient is a 39Â years old female Primi-para Ethiopian, who presented with lower abdominal dull aching pain of one-year duration which got worse over the last few months associated with right lower abdominal swelling, easy fatigability, LGIF, loss of appetite and weight. She is a known case of RVI on HAART for the past 18yrs and hypertensive for the last 8Â years for which she was taking enalapril and atenolol. Her only child was delivered by C/section 10Â years ago.
On examination , she looked chronically sick with her vitals in the normal range. The abdomen was flat with a lower midline surgical scar and a visible round mass on the right paraumblical and lower quadrant areas. The mass was well defined, smooth surfaced, slightly tender and mobile (Fig. 1 âblack arrow).
![lit 21 reviews figure 1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig1_HTML.jpg)
Black arrow shows the splenic mass, red arrow shows the stomach, cyan arrow shows previous CS scar
Her hematologic tests revealed WBC of 8.7âĂâ103, Hgb of 12.3 and PLT count of 544âĂâ10 3 . Serum electrolyte and liver function tests were all in the normal range. Creatinine was 1.4 mg/dl.
Abdominal ultrasound
Multiple bilateral renal, liver and pancreatic cysts. An ehcocomplex mainly hypoechoic, 13 cmx8cm well defined right sided abdomino-pelvic mass, with absent color Doppler flow. Spleen was not visualized in its normal anatomic site.
Contrast enhanced abdomino-pelvic CT
Described the mass as a hypoattenuating, well circumscribed lesion with no contrast enhancement located at right abdomino pelvic cavity (Fig. 2 ). Its long torsed pedicle could be traced to the region of the tail of the pancreas and the spleen was missing from its normal location. (Fig. 3 ) Majority of the renal parenchyma is almost replaced with different sized cystic lesions with imperceptible wall causing bilateral renal enlargement. (Fig. 3 ) The liver and the pancreas too is filled with similar cysts. The portal vein were not visualized and replaced by periportal enlarged collateral vessels. (Figs. 3 , 4 ).
![lit 21 reviews figure 2](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig2_HTML.jpg)
Infarcted spleen
![lit 21 reviews figure 3](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig3_HTML.jpg)
Absent spleen in the splenic fossa
![lit 21 reviews figure 4](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig4_HTML.jpg)
Spleen seen in the abdomino-pelvic cavity
With a diagnosis of wandering spleen located in the right abdomino pelvic region with torsion of the pedicle and infarction, she was admitted and underwent laparotomy. Intraoperatively, dense adhesion encountered between the anterior abdominal wall, omentum, the wandering spleen and small bowel. The spleen was whitish, distended and grossly infarcted with its long stalk torsedâ>â360°. (Fig. 5 ) Adhesions were gently released and splenectomy done. The splenic mass was sent for biopsy.
![lit 21 reviews figure 5](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig5_HTML.jpg)
The intra-op picture of our patient upon exploration
She was discharged on the 3rd postoperative day and her post-operative course was uneventful. She was seen after a month on follow up clinic with no report of complication. Her biopsy result showed splenic tissue. She got her pentavelant vaccine on the third week.
Wandering spleen is a rare clinical entity characterized by splenic hypermobility from its left hypochondriac position to any other abdominal or pelvic position caused by absent or abnormal laxity of the suspensory ligaments [ 1 , 2 ].
The first case of wandering spleen was reported by Von Horne in 1667. So far less than 600 cases are reported world wide [ 1 , 3 ].
Anatomically a normal spleen is found in the left hypochondriac region suspended by ligaments to the stomach, kidney, pancreas, colon and left hemi-diaphram by the gastrosplenic, splenorenal, pancreaticosplenic, splenocolic, splenophreni ligaments and presplenic folds [ 1 ]. Our patient presented with RLQ palpable abdominal mass which is against the commonest presentation being in the LLQ of the abdomen (Fig. 1 ).
It could result from either a developmental failure of the embryonic septum transversum to fuse properly with the posterior abdominal wall which results in absent/lax ligaments [ 4 ] or from acquired conditions that result in lax suspensory ligaments as in pregnancy or connective tissue disorders [ 3 ]. The spleen is found in any quadrant of the abdomen or the pelvis though mostly in the left quadrants attached only by a long and loose vascular pedicle. Our patient presented with RLQ mass.
It is mostly seen in multiparous women [ 4 ] though the incidence is found to be nearly equal in both sexes in the prepubertal age group [ 3 ]. Our patient was a Para 1 mother and presented with 01Â year history of abdominal pain which got worse in the past 06Â months. Otherwise she had no any other pressure symptoms. She had visible umbilical area mass which was mobile up on examination
Wandering spleen can have different presentation ranging from asymptomatic incidental finding on imaging or upon surgical exploration for other surgical conditions to a presentation that mimics acute abdomen [ 3 , 5 ]. Mostly it presents as an on and of type acute/ subacute non-specific abdominal pain due to torsion and spontaneous de-torsion of the loose splenic pedicle [ 3 , 4 ]. This chronic torsion results in congestion and splenomegaly [ 3 , 5 ]. Hence patients could have palpable mobile mass [ 6 ] which is the typical presentation of this patient. The other presentations are usually related to the mass effect of the enlarged spleen and patients could present with GOO, bowel obstruction, pancreatitis and urinary symptoms [ 3 , 6 ].
In some cases it is reported to be associated with some other disorders like gastric volvulus [ 7 ] and distal pancreatic volvulus [ 8 ].
Ultrasound is one of the imaging modalities to investigate patients whom we suspect had wandering spleen. It usually shows absent spleen in the splenic fossa and a comma shaped spleen in the abdomen or pelvis [ 9 ]. Doppler study might help us see the vascular condition and ads up to a better preoperative plan. CT scan shows absence of the spleen in the left upper quadrant, ovoid or comma-shaped abdominal mass, enlarged spleen, a whirled appearance of non-enhancing splenic vessels and signs of splenic hypo-perfusion: homogenous or heterogeneous decreased enhancement depending on the degree of infarction [ 3 , 9 , 10 ].
Our patient was scanned with US and showed 13*8 cm large midline abdomino-pelvic well defined oval mass which was predominantly solid with areas of cystic component with absent color Doppler flow. Otherwise the spleen was not visualized in the splenic fossa. Bilateral kidney and liver has multiple different sized cystic lesions. With this image Abdomino-pelvic CT was done and shows spleen is located in the lower abdomen and appears to have torsed vascular pedicle and the whole splenic parenchyma is hypodense and no enhancement seen. Majority of the renal parenchyma is almost replaced with different sized cystic lesions with imperceptible wall causing bilateral renal enlargement. The whole liver is filled with cystic lesions with imperceptible wall. The portal veins were not visualized and replaced by periportal enlarged collateral vessels (Figs. 6 , 7 ).
Usually surgical management is the rule once a patient is diagnosed with wandering spleen [ 3 , 5 ]. Most patients; 65% as reported in some studies will have torsion of the vascular pedicle at some point of their life [ 5 , 6 ]. Hence splenopexy or splenectomy shall be considered when a wandering spleen is found incidentally up on surgical exploration for some other purposes [ 6 ]. Complicated wandering spleen like infarcted, signs of hypersplenism, huge in size and splenic vein thrombosis needs splenectomy while others can be managed with splenopexy [ 3 , 5 , 6 ]. Nowadays though laparoscopic technique is the gold standard, open technique can be used for splenopexy and splenectomy [ 3 , 5 ].
Partial infraction of a wandering spleen might necessitate partial splenectomy and splenopexy or splenectomy and splenic implantation [ 6 , 11 ].
The spleen might get fixed by different methods [ 8 , 9 ].
Simple splenic fixation involves simple tacking the splenic capsule to the peritoneum
Retroperitoneal pouch splenopexy- Tissue [ 11 , 12 ]/Mesh splenopexy (sandwich technique) [ 13 ].
Omental and peritoneal pouch splenic fixation [ 14 ].
In our case, Spleen was absent from the normal anatomic splenic fossa and the spleen in the abdomino-pelvic area looks infarcted. Hence she was managed with splenectomy and the patient was extubated on table and having a stable postoperative course .
![lit 21 reviews figure 6](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13256-024-04580-6/MediaObjects/13256_2024_4580_Fig6_HTML.jpg)
Wandering spleen is a rare form of splenic pathology. Such a rare pathology presents commonly as an acute torsion with infarction. Spleen in the RLQ with chronic torsion and infarction is a very rare presentation for wandering spleen. In addition there is no report of such a presentation in a patient with AD-PCKD.
Recommendation
We recommend Clinicians to consider wandering spleen in their differential diagnosis in a patient presenting with RLQ abdominal mass and chronic abdominal pain.
Availability of supporting data
Data related with this case report is available at Addis ababa university, Tikur Ambesa Tertiary Hospital.
Abbreviations
Autosomal dominant polycystic kidney disease
Blood pressure
Low grade intermittent fever
High active anti-retroviral therapy
Right lower quadrant
Retro viral infection
Hypertension
White blood cell count
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Acknowledgements
We would like to thank the managing team of this patient including all the ward staffs who played a great role in the peri-operative management of this patient. We also appreciate the support of our consultants, residents and member of the department of surgery and HPB unit. Our kind gratitude goes to the family of this patient for their unreserved support in post-operative period that helped for the fast recovery of this patient
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Yitagesu aberra shibiru, Sahlu wondimu & Wassie almaw
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Dr. Yitagesu Aberra, Main author of this case report, is an HPB surgery fellow in the department of surgery, college of health science, Addis Ababa University who was the leading surgeon in the management of this patient. Dr. Sahlu Wendimu is an HPB surgery subspecialist and Assistant professor of General Surgery who was the consultant in duty during the management of this patient. Dr.Wassie Almaw is a 2nd year pediatric surgery resident attaching at HPB surgery unit who took part in the management of this patient.
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shibiru, Y.a., wondimu, S. & almaw, W. Wandering spleen presenting in the form of right sided pelvic mass and pain in a patient with AD-PCKD: a case report and review of the literature. J Med Case Reports 18 , 259 (2024). https://doi.org/10.1186/s13256-024-04580-6
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DOI : https://doi.org/10.1186/s13256-024-04580-6
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Severe fever with thrombocytopenia syndrome with central nervous system symptom onset: a case report and literature review
- Dawei Shan 1 ,
- Weibi Chen 1 ,
- Gang Liu 1 ,
- Huimin Zhang 1 ,
- Shuting Chai 1 &
- Yan Zhang 1 Â
BMC Neurology volume  24 , Article number: 158 ( 2024 ) Cite this article
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Severe fever with thrombocytopenia syndrome (SFTS) is a natural focal disease transmitted mainly by tick bites, and the causative agent is SFTS virus (SFTSV). SFTS can rapidly progress to severe disease, with multiple-organ failure (MOF) manifestations such as shock, respiratory failure, disseminated intravascular coagulation (DIC) and death, but cases of SFTS patients with central nervous system (CNS) symptoms onset and marked persistent involuntary shaking of the perioral area and limbs have rarely been reported.
Case presentation
A 69-year-old woman with fever and persistent involuntary shaking of the perioral area and limbs was diagnosed with SFTS with CNS symptom onset after metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) and peripheral blood identified SFTSV. The patient developed a cytokine storm and MOF during the course of the disease, and after aggressive antiviral, glucocorticoid, and gamma globulin treatments, her clinical symptoms improved, her laboratory indices returned to normal, and she had a good prognosis.
This case gives us great insight that when patients with CNS symptoms similar to those of viral encephalitis combined with thrombocytopenia and leukopenia are encountered in the clinic, it is necessary to consider the possibility of SFTS involving the CNS. Testing for SFTSV nucleic acid in CSF and blood (mNGS or polymerase chain reaction (PCR)) should be carried out, especially in critically ill patients, and treatment should be given accordingly.
Peer Review reports
Severe fever with thrombocytopenia syndrome (SFTS) is a natural focal disease transmitted mainly by tick bites, and the causative agent is a novel Bunyavirus, also known as SFTS virus (SFTSV), belonging to the Phenuiviridae family and the Bandavirus genus, which was first isolated from patient serum by the Chinese Centre for Disease Control and Prevention in 2010 [ 1 ]. The main features of SFTS include fever, thrombocytopenia, leukopenia and gastrointestinal symptoms, and in severe cases, patients may present with multipleâorgan failure (MOF) symptoms such as shock, respiratory failure, disseminated intravascular coagulation (DIC) and death, with a mortality rate of 5â30% in East Asia [ 2 , 3 ]. SFTS may also present with central nervous system (CNS) involvement, which can severely affect the patientâs disease progression and prognosis and is manifested by seizures, psychiatric symptoms, cognitive impairment, and disorders of consciousness [ 4 , 5 ]. However, reports of patients who present with CNS symptoms as the first symptom and with marked persistent involuntary shaking of the perioral area and limbs are rare.
A 69-year-old female patient was admitted to the hospital with fever for 4 days, involuntary shaking around the mouth and limbs for 3 days, and mental abnormalities for 1 day. The patient was admitted to the emergency department of another hospital 4 days before admission because of fever, where her body temperature reached 38.7 °C and she showed poor mental status, less talking, a loss of appetite, but no headache, vomiting, and limb twitching. A routine blood examination showed a white blood cell (WBC) count of 2.28âĂâ10 9 /L and a platelet count of 165âĂâ10 9 /L. When given a cooling infusion for symptomatic treatment, her body temperature would temporarily return to normal. Three days before admission, she experienced persistent involuntary trembling around the mouth and lips, as well as trembling of the tongue and extremities. The trembling of the lips, mouth, and both distal upper limbs was especially bothersome and was aggravated by emotional excitement and accompanied by slurred speech. Two days before admission, she had persistent fever, with a body temperature up to 39.6 °C, and the effect of antipyretic drugs was not good. A routine blood examination performed in another hospital showed a WBC count of 1.78âĂâ10 9 /L and a platelet count of 81âĂâ10 9 /L, which was significantly decreased compared with the count from the previous examination. One day prior to admission, the patient experienced babbling, restlessness, irritability, and a decline in time and place orientation and calculation power.
The patient had a many-year history of hypertension, diabetes mellitus and hyperlipidaemia; denied a history of working and living in hilly, forested and mountainous areas and travelling; denied a recent history of mosquito bites; and reported a history of close contact with a pet dog in the last month.
Neurological examination after admission showed that the patient had normal arousal but had unclear speech, hyperactivity, irritability. Her time and place orientation and calculation power decreased. The patient was uncooperative in the pharyngeal reflex examination, and involuntary tongue twitching could be seen when the tongue was stretched out. The remaining cranial nerve examination did not show any abnormalities. Perioral and limb involuntary shaking was obvious and persistent, especially in the perioral area and distal part of both upper limbs. Bilateral tendon reflexes were symmetrical, bilateral pathological signs were negative, and meningeal irritation signs were negative.
On admission, viral encephalitis was considered, and intravenous acyclovir antiviral therapy (0.5 g, q8h) was empirically administered. A comprehensive examination revealed that the patient had MOF: (1) Her platelet count further decreased to 63âĂâ10 9 /L (normal: 100â300âĂâ10 9 /L), toxic granules were seen in some granulocytes of the peripheral blood smear, and heterogeneous lymphocytes accounted for 21% of the total. (2) She had impaired liver function with elevated liver enzymes (alanine aminotransferase (ALT), 76 IU/L (normal: 5â40 IU/L); aspartate aminotransferase (AST), 188 IU/L (normal: 8â40 IU/L); and gamma-glutamyl transpeptidase (Îł-GT), 177 IU/L (normal: 7â50 IU/L)), which was treated with magnesium isoglycyrrhizinate injection and vitamin C for liver protection. (3) She had acute myocardial injury, with an increased heart rate of >â120 beats/minute and markedly elevated myocardial enzyme and B-type natriuretic peptide levels (myoglobin, 299 ng/mL (normal: 25â58 ng/mL); troponin T, 209 ng/L (normal: 0â14 ng/L); and B-type natriuretic peptide, 9,355 pg/mL (normal: 0-125 pg/mL)). Electrocardiograms (ECGs) showed various atypical manifestations, such as short PR intervals; atrial premature, mild ST-segment depression in leads V2V3; and T-wave changes in multiple leads. Cardiac ultrasound showed a normal left ventricular ejection fraction but abnormal segmental motion of the left ventricular wall, biventricular diastolic insufficiency and a small amount of pericardial effusion. Coenzyme Q10 and trimetazidine were given to improve myocardial energy metabolism, and fluid intake and output were closely monitored. (4) The patient had a bacterial infection of the lungs, combined with type I respiratory failure, which were treated with tracheal intubation and mechanical ventilation immediately to assist respiration and antibiotic antimicrobial therapy. The patient did not have prolonged hypoxic injury. (5) She had impaired renal function, with elevated blood urea nitrogen (BUN) (17.33 mmol/L) (normal: 1.7â8.3 mmol/L) and urinary protein. We administered measures to ensure fluid intake and without the use of nephrotoxic drugs. (6) She had impaired pancreatic function, with elevated lipase (56.5 U/L) (normal: 5.6â51.3 U/L); we administered acid-suppressing drugs to inhibit pancreatic secretion and reduce the load and damage to pancreatic tissue. (7) She had abnormal coagulation, with a prolonged prothrombin time (PT) and thrombin time (TT) (15.7 s (normal: 11â15 s) for PT and 22.6 s (normal: 14â21 s) for TT), decreased fibrinogen (1.8 g/L) (normal: 2â4 g/L), and markedly elevated plasma D-dimer (9.01 ¾g/mL) (normal: 0.01â0.5 ¾g/mL) and fibrinogen degradation products (FDPs) (28.36 ¾g/mL) (normal: 0â5 ¾g/mL). (8) A thrombus had formed in her right peroneal vein and the intermuscular veins of the right and left calves, for which low molecular heparin anticoagulation was given. (9) Her muscle enzyme profiles were variably elevated (creatine kinase (CK), 335 IU/L (normal: 24â195 IU/L); lactate dehydrogenase (LDH), 1347 IU/L (normal: 109â245 IU/L); and alpha-hydroxybutyrate dehydrogenase (Îą-HBDH), 645 IU/L (normal: 72â182 IU/L)), correlating with inflammatory response-mediated organ damage. (10) The patient experienced a cytokine storm, with significantly increased inflammatory factors (ferritinâ>â1500 ng/mL (normal: 11-306.8 ng/mL), interleukin (IL)-6â=â49.88 pg/mL (normal: 0â20 pg/mL), IL-8â=â45.99 pg/mL (normal: 0-21.4 pg/mL), and IL-10â=â25.67 pg/mL (normal: 0-5.9 pg/mL), interferon (IFN)-Îąâ=â9.76 pg/mL (normal: 0-7.9 pg/mL), and IFN-Îłâ=â18.7 pg/mL (normal: 0-17.3 pg/mL)) in serum (Table 1 ). (11) Finally, the patient showed an electrolyte balance disorder, as evidenced by hypernatremia (154 mmol/L) (normal: 135â145 mmol/L), hyperchloremia (119 mmol/L) (normal: 96â108 mmol/L), hypocalcaemia (1.92 mmol/L) (normal: 2.03â2.67 mmol/L), and hypophosphatemia (0.54 mmol/L) (normal: 0.84â1.65 mmol/L), and treatments included calcium supplementation, phosphorus supplementation, nasal administration of plain water, and a reduction of sodium and chlorine intake.
Lumbar puncture was performed on the second day after admission (Table 2 ). Cerebrospinal fluid (CSF) was colourless and clear, with a pressure of 190 mmH 2 O (normal: 80â180 mmH 2 O) and a WBC count of 3âĂâ10 6 /L. CSF cytology showed scattered lymphocytes and a few mononuclear cells. The glucose level and protein counts were normal, chloride was slightly elevated (134 mmol/L) (normal: 118â128 mmol/L), immunoglobulins (Ig) were slightly elevated (IgA, 1.03 mg/dL (normal: 0-0.2 mg/dL); IgM, 0.22 mg/dL (normal: 0-0.2 mg/dL); and IgG, 6.68 mg/dL (normal: 0.48â5.86 mg/dL)), and CSF cytokine levels of IL-6 (27.46 pg/mL) (normal: 0â20 pg/mL) and IL-8 (546.93 pg/mL) (normal: 0-21.4 pg/mL) were elevated. CSF was negative for an autoimmune encephalitis antibody profile (NMDAR, CASPR2, AMPAR1, AMPAR2, LGI1, GABABR, DPPX, and IgLON5), neuroparaneoplastic syndrome antibody profile (Hu, Ri, Yo, CV2, Amphiphysin, GAD65, PNMA2, Recoverin, SOX1, Titin, Tr, and Zic4), and CNS demyelination antibody profile (AQP4, GFAP, MBP, and MOG). Metagenomic next-generation sequencing (mNGS) showed that the number of sequences of a novel Bunyavirus of the Bandavirus genus was 59 in the blood and 12 in the CSF. We also excluded acute febrile illnesses by serum and CSF mNGS, such as dengue fever, chikungunya fever, EB virus infection, renal syndrome hemorrhagic fever, and rickettsial disease.
A diagnosis of SFTS that started with symptoms of CNS and encephalitis due to a novel Bunyavirus was considered based on the patientâs clinical presentation and laboratory test results. With immediate effect, acyclovir was adjusted to the broad-spectrum antiviral drug Foscarnet sodium (3Â g, q8h); intravenous infusion of dexamethasone (10Â mg qd for five days) and intravenous immunoglobulin (IVIG) (0.4Â g/kg for five days) were administered to regulate immune function and inhibit the cytokine storm; nifedipine and benidipine hydrochloride were given to reduce the viral-induced calcium inflow to inhibit viral replication, reduce the viral load and increase the platelet count; clonazepam (1Â mg, q8h) was given to relieve the patientâs obvious symptoms of involuntary shaking; and adequate symptomatic supportive therapy was given to ensure adequate calorie and protein intake and to maintain water, electrolyte, blood glucose and acidâbase balance.
After 3 days of hospitalization, the patientâs platelet and WBC counts began to rise gradually and returned to normal levels. After 5 days of hospitalization, the patientâs involuntary shaking and psychiatric symptoms were less severe than before, but compliance with activities was still poor, and her cognitive level still had not returned to normal. After 11 days of hospitalization, the lung infection was better than before, and ventilator withdrawal training was started. After 12 days of hospitalization, cranial magnetic resonance imaging (MRI) was performed, which showed slightly high signals in the bilateral anterior temporal lobe, temporal lobe hook gyrus, insular cortex, and bilateral thalamus on fluid attenuated inversion recovery (FLAIR) and diffusion weighted imaging (DWI) (Fig. 1 a-f). After 13 days of hospitalization, a blood sample was negative for novel Bunyavirus nucleic acid. After 16 days of hospitalization, her condition was significantly better than before, she could perform activities as instructed and answer questions correctly, her time and place orientation returned to normal, and her cognitive level was better than before. A electroencephalogram (EEG) was performed, and a full-lead low-wave amplitude state was observed (Fig. 2 ). After 17 days of hospitalization, the ventilator was completely withdrawn, and the tracheal tube was removed. A repeat lumbar puncture 3 weeks after hospitalization showed a pressure of 110 mmH 2 O, a WBC count of 4âĂâ10 6 /L, a normal protein count, a slightly elevated glucose level (5.19 mmol/L, compared with a glucose of 7.9 mmol/L over the same period), a slightly elevated chlorine level (130 mmol/L), and a return of Ig to normal. The levels of cytokines IL-6 (4.35 pg/mL) and IL-8 (96.17 pg/mL) decreased significantly compared with the previous levels, and the levels of whole-blood cytokines returned to the normal range (IL-6, 12.22 pg/mL; IL-8, 4.62 pg/mL; IL-10, 1.27 pg/mL; IFN-Îą, 0 pg/mL; and IFN-Îł, 1.14 pg/mL) in serum (Table 1 ). No further novel Bunyaviruses were detected by mNGS of the CSF. Meanwhile, MOF gradually recovered, and liver, heart, lung, kidney, pancreas and coagulation function; the muscle enzyme profile; inflammatory factors; and electrolyte levels gradually returned to normal levels.
After antiviral therapy, immunotherapy, life support and symptomatic treatment, the patientâs vital signs were stable 3 weeks after admission, with clear speech and normal higher cortical function to perform tasks correctly on command. The muscle strength of all four limbs was grade 5, muscle tone was normal, bilateral tendon reflexes existed symmetrically, an ataxia test was normal, bilateral pathological signs were negative, and meningeal irritation signs were negative. She was discharged from the hospital in 23 days after admission. The patient was followed up 1 month after she was discharged from the hospital and is now back to her normal living conditions, with normal functioning of the higher cortex, the ability to take care of herself, and the ability to perform all of the activities she regularly engages in.
![lit 21 reviews figure 1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12883-024-03664-6/MediaObjects/12883_2024_3664_Figa_HTML.jpg)
Cranial MRI of the patient 12 days after admission. Bilateral anterior temporal lobe (a and d) , temporal lobe leptomeningeal gyrus (a and d) , insular cortex (b and e) , and bilateral thalamus (c and f) FLAIR and DWI sequences with slightly high signals
![lit 21 reviews figure 2](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12883-024-03664-6/MediaObjects/12883_2024_3664_Figb_HTML.png)
Sixteen-lead resting-state EEG of the patient 16 days after admission. Simultaneous display an EEG record in monopolar and bipolar montages. A low-amplitude state can be seen in all leads. (a) monopolar montage EEG, (b) bipolar montage EEG
Discussion and conclusions
SFTS is an infectious disease caused by SFTSV infection. The epidemic period is mainly in May-August, and SFTSV is mainly transmitted by tick bites to humans. In recent years, interpersonal and human-animal transmission has also been found. An epidemiological survey of SFTS found that 48% of the patients had had close contact with their pets within two weeks of the onset of the disease [ 6 ]. The general population is susceptible, with a higher risk of infection in residents living in areas such as hills, mountains and forests and in people who spend time outdoors. In this case, SFTSV was isolated from blood and CSF. There was no history of tick bites or travel in the wild, but there was a history of close contact with a pet dog within the past month, and we hypothesized that the infected dog might have been the source of SFTSV in this patient.
The pathogenesis of CNS involvement in SFTS patients is unclear. Previous studies have demonstrated that Bunyaviruses have neurological properties of attack, and Park et al. found viral transcripts of novel Bunyaviruses in the brain and spinal cord of an aged model ferret. It is hypothesized that novel Bunyaviruses also involve the CNS, with consequent symptoms [ 7 ]. Possible mechanisms by which SFTSV attacks the CNS include direct invasion, cytokine storms, and impaired immune function. Kaneko et al. [ 8 ] performed an autopsy on a patient with SFTS with rapid CNS involvement, and the pathological findings revealed a massive infiltration of macrophages with high haematoxylin content and inflammatory cells around the microvessels of the cerebral pontine, fibrin deposition in the vessels, and focal degenerative lesions in some neuronal cells. In a variety of brain tissues, positive SFTSV nucleocapsid protein antigens were observed in the immunoblasts infiltrating the vascular lumen, suggesting that SFTSV can invade the CNS directly for disease development. The availability of agents that recognize these antigens also suggest immunoassays are possible and available for serodiagnosis. For example, serum enzyme linked immunosorbent assay or immunofluorescence to determine SFTSV antigens and antibodies have been used for clinical diagnosis [ 9 ]. Several studies [ 10 , 11 , 12 , 13 , 14 , 15 ] have found that the blood levels of several cytokines, including IFN-Îą, IFN-Îł, IL-6, IL-8, IL-10, tumour necrosis factor (TNF)-Îą, and monocyte chemotactic protein (MCP)-1, are elevated in patients with SFTS, and IL-8 and MCP-1 levels in the CSF are significantly higher than the blood of those who present with CNS symptoms [ 10 ], suggesting that a cytokine storm may increase vascular permeability and prompt SFTSV to cross the bloodâbrain barrier (BBB) and invade the CNS. SFTSV was found in the CSF of this patient, suggesting that the virus had invaded the patientâs CNS. The patientâs blood levels of IL-6, IL-8, IL-10, IFN-Îą, and IFN-Îł were markedly elevated compared with normal ranges; IL-6 and IL-8 were elevated in the CSF; and CSF IL-8 levels were significantly higher than the blood levels, which was consistent with the results of a previous study [ 10 , 11 , 12 , 13 , 14 , 15 ], further suggesting that the cytokine storms induced by multiple elevated cytokines may increase BBB vascular permeability and contribute to the SFTSV invasion of the CNS. In patients with SFTS complicated by neurological involvement, protein and glucose levels in the CSF are normal and that an increase in leukocytes in the CSF may be uncommon. However, in the case of a high suspicion both on a clinical and epidemiological level in countries where the infection exists, in these patients the search for MCP-1 and IL-8 in the CSF and serum is indicated and CSF viral RNA detection are recommended.
According to the course of infection, SFTS can be divided into four periods: the incubation period, the febrile period, the MOF period, and the recovery period [ 1 , 2 , 3 , 16 ]. Patients with SFTS can present with neurological symptoms, which usually appear approximately 5 days after the onset of the disease (Table 3 ) and are often regarded as a complication of SFTS, which has been referred to as SFTS-associated encephalopathy/encephalitis (SFTSAE) [ 10 ]. SFTSAE mainly manifests as headache, seizures, mental abnormality, irritability, limb convulsions, cognitive impairment, and impaired consciousness, with an incidence of approximately 19.1-57.02% [ 4 , 5 , 11 , 17 ]. Most patients with SFTSAE develop impaired consciousness, such as coma, before their condition is taken seriously, which leads to a poor prognosis for the patients [ 4 , 18 ]. Most clinicians rely on the clinical manifestations to make the clinical diagnosis. SFTSV has rarely been isolated from CSF. We screened studies and case reports of SFTS with CNS involvement and found no reports of disease onset with CNS symptoms such as marked persistent involuntary shaking of the perioral area and extremities. In this case, the patient first presented with fever, followed by persistent involuntary tremors of the perioral area and limbs and mental behavioural abnormalities such as rambling, irritability and agitation; furthermore, the whole-genome sequence of SFTSV was found by mNGS of blood and CSF. The case reported here is a case of SFTS with CNS symptoms onset, accompanied by perioral and extremity persistent involuntary shaking, which has not been previously reported in the literature. It has been reported in the literature that SFTS patients can have tremors of limbs and muscles [ 8 , 17 , 19 ], but most of them occurred in the middle and late stages of the disease, and the tremor amplitude was small. In this case, the patient had large-amplitude involuntary shaking of the limbs that was persistent and intensified during agitation, which immediately attracted the clinicianâs attention. An additional movie file shows this in more detail [see Additional file 1 ]. However, the specific underlying mechanism is not clear, and a description of similar symptoms of viral encephalitis and an analysis of the underlying mechanism have not been found before; therefore, further studies are needed. The course of the disease in this patient was consistent with the general pattern, with the clinical experience of the febrile period, the MOF period, and the recovery period. The febrile period lasted approximately 4 days, followed by MOF involving the liver, heart, lungs, kidneys, and pancreas, and then the recovery period began approximately 2 weeks after the disease onset, with clinical symptoms gradually returning to normal.
There are fewer reports on neurological-related ancillary investigations (CSF, cranial imaging, and EEG) in SFTS patients with CNS involvement, and we analyse this because SFTS patients rarely start with CNS symptoms and go directly to the neurology department and because such patients are generally more severely ill, making it difficult for them to cooperate in completing the relevant investigations. In a few previous studies, lumbar puncture CSF tests in SFTS patients with CNS symptoms were mostly normal, with few abnormal changes in leukocyte counts, sugars and proteins [ 10 , 20 ]. Park et al. [ 10 ] analysed head imaging and EEG in a series of SFTS patients presenting with CNS symptoms, and no new focal lesions were seen on imaging in any of the brain parenchyma, suggesting that the imaging was not specific and that the EEG in the majority of the patients showed a slow-wave background rhythm (δ-θ), a common feature of encephalitis/encephalopathy. In this patient, two lumbar punctures were performed successively, and no CSF leukocyte abnormalities were observed in any of them either; it was presumed that SFTSV infection was less likely to involve the meninges. We performed cranial MRI and EEG on the patient 12 and 16 days after admission, respectively, and slightly high signals were observed in the bilateral anterior temporal lobes, temporal lobe hook gyrus, insular cortex, and bilateral thalamus in the FLAIR and DWI sequences of cranial MRI, all of which were consistent with the general imaging manifestations of viral encephalitis and were presumed to be related to viral invasion. In addition, we should consider the similarities and differences between the above MRI changes and cortical laminar necrosis associated with hypoxia or hypotension. We found that both had MRI high signals distributed along the cortex. However, this patientâs cranial MRI showed cortical high signals only in FLAIR and DWI sequences, and no abnormal signal was found in T1WI, which was the most obvious difference from cortical laminar necrosis. Furthermore, the patient did not show hypotension or significant hypoxic injury, so the changes on cranial MRI were more likely to be inflammatory changes of viral encephalitis and less relevant to cortical laminar necrosis. The background rhythm of the EEG was an Îą rhythm, and the whole leads were in low amplitude, which was different from previous studies [ 10 ]. It was presumed that the patientâs brain inflammation had tended to recover at that time, but the suppression of cortical function was remained.
There are no specific drugs for the treatment of CNS symptoms in SFTS, and symptomatic supportive treatment is the mainstay. In vitro and ex vivo studies have found that nifedipine or benidipine hydrochloride can inhibit SFTSV replication, reduce viral load, increase platelet counts, and reduce morbidity and mortality, as confirmed in a retrospective clinical study [ 21 , 22 ]. Glucocorticoids can inhibit the cytokine storms caused by the overproduction of cytokines and reduce patient mortality [ 12 , 13 , 23 ], and a Japanese report documented that three SFTS patients with impaired consciousness recovered without any neurological sequelae after short-term glucocorticoid treatment. However, the authors also suggested that the dosage should be minimized and the duration of administration should be shortened to inhibit cytokine storms and provide systemic benefit, rather than high doses or prolonged use, to avoid side effects [ 24 ]. Gamma globulin, which triggers complement activation and viral neutralization and influences the differentiation process of Schwann cells to increase their regenerative potential [ 25 ], has been used to treat other virus-induced encephalitides and can be used for the treatment of CNS symptoms in SFTS. Two successful cases of combined glucocorticoid and IVIG therapy were reported in Korea [ 26 ]. Two case reports documented that plasma exchange therapy reduced cytokine levels but not viral load, presumably making plasma exchange more effective at an early stage [ 27 , 28 ]. However, these are case reports, and the findings should be confirmed by large-scale randomized controlled studies. In this case, the patient was given the broad-spectrum antiviral drug foscarnet sodium, intravenous infusion of dexamethasone and IVIG to regulate the immune function of the body and inhibit the inflammatory storm, nifedipine and benidipine hydrochloride to inhibit viral replication and reduce the viral load, and other symptomatic treatments. The patientâs clinical manifestations and laboratory indicators gradually improved.
The prognosis of patients with SFTS is related to numerous factors, and studies have shown that advanced age; significant elevations in ALT, AST, CK, CK-MB, LDH, Îł-GT, and BUN; low platelet count; persistent lowering of blood calcium; and the presence of CNS symptoms are all important influences that can lead to a poor prognosis [ 29 , 30 , 31 , 32 , 33 , 34 ]. Most of these are commonly used to monitor cardiac, hepatic and renal function, and significant abnormalities in their results indicate more severe organ damage and dysfunction. In addition, there is a statistically significant difference in serum viral copy number between deceased and non-dead patients. The mean viral copy number was higher in deceased patients than in surviving patients, and patients with higher copy numbers had higher mortality rates [ 35 , 36 ]. It was shown that the serum viral load detected by polymerase chain reaction (PCR) on admission was higher in SFTSAE patients than in non-encephalitis patients [ 11 ]. The above suggests a relationship between patient serum number of SFTSV RNA copies and encephalitis CNS symptoms and mortality in SFTS patients. CNS symptoms are often considered to be associated with fatal outcomes in patients with SFTS [ 33 ], and early diagnosis and treatment of neurological symptoms can help reduce mortality. Advanced age; long intervals between onset and admission; comorbid diabetes mellitus or subcutaneous haemorrhage; pulmonary rales; low platelet count; elevated neutrophil percentages and LDH, CK, and C-reactive protein (CRP) levels; and decreased chloride concentrations are significantly associated with the development of CNS symptoms and should be taken into consideration in clinical practice [ 11 , 17 ]. We believe that changes in platelet count and CK-MB should be monitored in patients with SFTSAE. As shown in previous, decreased platelet counts and high CK-MB levels are risk factors for poor prognosis in patients with SFTS. The presence of encephalitis is evidence of a more critical condition. Monitoring changes in platelet counts may provide an initial indication of the direction of the patientâs regression. It has been found that in cardiac enzyme profiles, patients presenting with CNS symptoms have elevated CK levels earlier than LDH and AST levels, and elevated liver enzyme levels later than cardiac enzymes [ 17 ]. Therefore, early monitoring of CK-MB levels may have a predictive effect on the development of CNS symptoms in patients. Although the mortality rate of SFTS patients presenting with CNS symptoms is significantly higher [ 11 ], several studies have found [ 11 , 37 , 38 ] that the long-term prognosis of surviving patients is good, with no obvious sequelae after active treatment. In this case, the patientâs laboratory indicators were consistent with the factors leading to a poor prognosis, and the CNS symptoms were prominent, suggesting that the condition was critical, but with timely administration of treatment, the patientâs condition eventually returned to normal.
In summary, we report a case of SFTS in a patient who started with CNS symptoms accompanied by marked persistent involuntary perioral and extremity shaking, and the whole-genome sequence of SFTSV was found by mNGS of both serum and CSF (It is important to note that hospitals where mNGS analysis is unavailable should use real-time fluorescent quantitative PCR to detect SFTS-specific nucleic acids in serum and CSF.). This has given us great insight into the fact that SFTS should be considered a possible cause when patients present with common CNS symptoms of viral encephalitis, such as mental behavioural abnormalities, convulsions, and cognitive deficits, or rare symptoms, such as persistent involuntary shaking of the perioral area and limbs in the rare case of this patient, combined with thrombocytopenia and leukopenia. Prompt lumbar puncture examination for SFTSV should be performed, and appropriate treatment should be given aggressively to reduce mortality.
Data availability
No datasets were generated or analysed during the current study.
Abbreviations
severe fever with thrombocytopenia syndrome
severe fever with thrombocytopenia syndrome virus
multiple-organ failure
disseminated intravascular coagulation
central nervous system
metagenomic next-generation sequencing
cerebrospinal fluid
alanine aminotransferase
aspartate aminotransferase
gamma-glutamyl transpeptidase
electrocardiogram
blood urea nitrogen
prothrombin time
thrombin time
fibrinogen degradation products
creatine kinase
lactate dehydrogenase
alpha-hydroxybutyrate dehydrogenase
interleukin
immunoglobulin
intravenous immunoglobulin
magnetic resonance imaging
fluid attenuated inversion recovery
diffusion weighted imaging
electroencephalogram
tumour necrosis factor
monocyte chemotactic protein
blood-brain barrier
severe fever with thrombocytopenia syndrome -associated encephalopathy/ encephalitis
polymerase chain reaction
C-reactive protein
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This project was supported by National Key Research and Development Program of China (2020YFC2005403), and by China Association for Promotion of Health Science and Technology (JKHY2023001).
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Dawei Shan and Yan Zhang contributed to the conception and design of the manuscript. Dawei Shan collected the data and drafted the manuscript. Yan Zhang, Weibi Chen, Gang Liu, Huimin Zhang and Shuting Chai reviewed and modified the manuscript. All authors contributed to manuscript revision and read and approved the final submitted version.
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Supplementary Material 1. File name: Additional file 1. File format: mp4. Title of data: Video of patient with persistent involuntary shaking of the perioral area and limbs. Description of data: We took this video on day 2 after the patient was admitted to the hospital. The patient develops persistent involuntary shaking of the perioral area and limbs, especially in the perioral area and distal limbs, which is aggravated by agitation and is accompanied by slurred speech.
Supplementary Material 2. CARE Checklist of information to include when writing this case report.
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Shan, D., Chen, W., Liu, G. et al. Severe fever with thrombocytopenia syndrome with central nervous system symptom onset: a case report and literature review. BMC Neurol 24 , 158 (2024). https://doi.org/10.1186/s12883-024-03664-6
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Start your review of Lit Lounge. Overall rating. 27 reviews. 5 stars. 4 stars. 3 stars. 2 stars. 1 star. Filter by rating. Search reviews. Search reviews. Tina A. Elite 24. San Francisco, CA. 299. 1099. 1392. Feb 13, 2024. 2 photos. Definitely 2000-2010's bay area party vibes. It felt highly nostalgic with the music videos playing hip hop and ...
Pure pleasure.". -Amy Scribner ( BookPage) **. Nonfiction. 1. Undue Burden: Life and Death Decisions in Post-Roe America by Shefali Luthra. (Doubleday) 5 Rave ⢠1 Positive. " Undue Burden isn't the first book about abortion rights and it certainly won't be the last.
Fish and seafood products are one of the most common causes of listeriosis in humans. A systematic review and meta-analysis were conducted using scientific literature to summarize available data on the prevalence of Listeria monocytogenes and Listeria sp. in fish, fish products and fish processing environment. Meta-analysis models were used to estimate the mean prevalence of the pathogen and ...
To conduct this study, the authors followed the essential steps of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) and Okoli's [] steps for conducting a systematic review.These included identifying the study's purpose, drafting a protocol, applying a practical screening process, searching the literature, extracting relevant data, evaluating the quality ...
May 21, 2024. Jenny Erpenbeck's " Kairos ," a novel about a torrid love affair in the final years of East Germany, won on Tuesday the International Booker Prize, the renowned award for ...
Wandering spleen is a rare clinical entity in which the spleen is hypermobile and migrate from its normal left hypochondriac position to any other abdominal or pelvic position as a result of absent or abnormal laxity of the suspensory ligaments (Puranik in Gastroenterol Rep 5:241, 2015, Evangelos in Am J Case Rep. 21, 2020) which in turn is due to either congenital laxity or precipitated by ...
Severe fever with thrombocytopenia syndrome (SFTS) is a natural focal disease transmitted mainly by tick bites, and the causative agent is SFTS virus (SFTSV). SFTS can rapidly progress to severe disease, with multiple-organ failure (MOF) manifestations such as shock, respiratory failure, disseminated intravascular coagulation (DIC) and death, but cases of SFTS patients with central nervous ...