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  1. Design and data analysis case-controlled study in clinical research

    Introduction. Clinicians think of case-control study when they want to ascertain association between one clinical condition and an exposure or when a researcher wants to compare patients with disease exposed to the risk factors to non-exposed control group. In other words, case-control study compares subjects who have disease or outcome (cases ...

  2. Research Design: Case-Control Studies

    Analysis of Case-Control Studies. Case-control studies are analyzed using logistic regression. The dependent variable is the (dichotomous) grouping variable: case vs. control. ... With larger samples, statistical power to adjust for confounding will improve. The other reason is that, in case-control studies, data are usually drawn from medical ...

  3. What Is a Case-Control Study?

    Revised on June 22, 2023. A case-control study is an experimental design that compares a group of participants possessing a condition of interest to a very similar group lacking that condition. Here, the participants possessing the attribute of study, such as a disease, are called the "case," and those without it are the "control.".

  4. A Practical Overview of Case-Control Studies in Clinical Practice

    Case-control studies are one of the major observational study designs for performing clinical research. The advantages of these study designs over other study designs are that they are relatively quick to perform, economical, and easy to design and implement. Case-control studies are particularly appropriate for studying disease outbreaks, rare diseases, or outcomes of interest. This article ...

  5. Analysis of matched case-control studies

    Options for analysing case-control studies. Unmatched case-control studies are typically analysed using the Mantel-Haenszel method10 or unconditional logistic regression.4 The former involves the familiar method of producing a 2×2 (exposure-disease) stratum for each level of the confounder (eg, if there are five age groups and two sex groups, then there will be 10 2×2 tables, each showing ...

  6. Methodology Series Module 2: Case-control Studies

    Case-Control study design is a type of observational study. In this design, participants are selected for the study based on their outcome status. Thus, some participants have the outcome of interest (referred to as cases), whereas others do not have the outcome of interest (referred to as controls). The investigator then assesses the exposure ...

  7. A Practical Overview of Case-Control Studies in Clinical Practice

    General Overview of Case-Control Studies. In observational studies, also called epidemiologic studies, the primary objective is to discover and quantify an association between exposures and the outcome of interest, in hopes of drawing causal inference. Observational studies can have a retrospective study design, a prospective design, a cross ...

  8. Case Control Study

    Case control studies are generally more cost-effective and time-efficient compared to other epidemiological study designs, such as cohort studies. Because they are retrospective, case control studies utilize existing records and participant recall, reducing the need for long-term follow-up and extensive data collection.

  9. Research Guides: Study Design 101: Case Control Study

    A case-control study was conducted to investigate if exposure to zinc oxide is a more effective skin cancer prevention measure. The study involved comparing a group of former lifeguards that had developed cancer on their cheeks and noses (cases) to a group of lifeguards without this type of cancer (controls) and assess their prior exposure to ...

  10. Qualitative case study data analysis: an example from practice

    Data sources: The research example used is a multiple case study that explored the role of the clinical skills laboratory in preparing students for the real world of practice. Data analysis was conducted using a framework guided by the four stages of analysis outlined by Morse ( 1994 ): comprehending, synthesising, theorising and recontextualising.

  11. Case Control Studies

    A case-control study is a type of observational study commonly used to look at factors associated with diseases or outcomes. The case-control study starts with a group of cases, which are the individuals who have the outcome of interest. The researcher then tries to construct a second group of individuals called the controls, who are similar to ...

  12. Statistical analyses of case-control studies

    This article discusses statistical analysis in case-control studies. Advantages and Disadvantages of Case-Control Studies. Study Design. ... Data collection. Decide on the data to be gathered after precisely identifying the cases and controls; both groups must have the same data obtained in the same method. If the search for primary risk ...

  13. Analysis of Case-Control Studies

    As with cohort studies and clinical trials one of the first steps in the analysis of a case-control study is to generate simple descriptive statistics on each of the groups being compared, i.e., the case and the controls. This helps characterize the study population, and it also alerts you and your readers to any differences between the groups ...

  14. PDF Strategies for data analysis: case-control studies

    In case-control studies we can calculate: • The odds ratio to measure association between disease and exposure: The odds of being exposed for a case is a/c The odds of being exposed for a control is b/d. The odds ratio of exposure for cases vs controls is ORExp = (a/c)/(b/d) = (a x d)/(b x c) Exposed. Non-exposed.

  15. Case-control study

    A case-control study (also known as case-referent study) is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute. Case-control studies are often used to identify factors that may contribute to a medical condition by comparing subjects who have the condition with patients who do not have ...

  16. PDF Design and Analysis of Case-Control Studies

    Case-Control Studies. Are used to retrospectively determine if there is an association between an exposure and a specific health outcome. Proceed from effect (e.g. health outcome, condition, disease) to cause (exposure). Collect data on exposure retrospectively. Are observational studies because no intervention is attempted and no attempt is ...

  17. Statistical analysis of case-control studies

    Data Interpretation, Statistical*. Humans. Methods of analysis of results from case-control studies have evolved considerably since the 1950s. These methods have helped to improve the validity of the conclusions drawn from case-control research and have helped to ensure that the available data are utilized to their fullest extent. Logistic r ….

  18. Case Control Studies

    A case-control study is a type of observational study commonly used to look at factors associated with diseases or outcomes.[1] The case-control study starts with a group of cases, which are the individuals who have the outcome of interest. The researcher then tries to construct a second group of individuals called the controls, who are similar to the case individuals but do not have the ...

  19. Analysis of case-control data with interacting ...

    Case-control studies are important and useful methods for studying health outcomes and many methods have been developed for analyzing case-control data. Those methods, however, are vulnerable to mismeasurement of variables; biased results are often produced if such a feature is ignored. In this paper, we develop an inference method for handling case-control data with interacting misclassified ...

  20. PDF Strategies for data analysis: case-control studies

    Strategy for data analysis for case-control studies Describe study profile : number of cases and controls, identified and analyzed Baseline characteristics of cases and controls Crude ORs for different categories of use and risk factors ORs for different categories of use and risk factors, adjusting for confounders

  21. Survival Analysis of Case-Control Data: A Sample Survey Approach

    ABSTRACT. This chapter presents a general sample survey approach to survival analysis of case-control data. It explains how the case-control data may be viewed as a two-phase sample, where the cohort data correspond to the Phase I sample and the case-control data to the Phase II sample. The chapter describes the statistical methods to estimate ...

  22. Variant analysis of human papillomavirus type 52 in Iranian women

    In agreement with this, the present study intended to investigate the sequence variations of the E6 gene to identify the common HPV 52 lineages and sublineages circulating in Iran. 2 MATERIALS AND METHODS 2.1 Study population. To investigate the lineages and sublineages of HPV 52, a case-control study was conducted from 2018 to 2020.

  23. Increased high-density lipoprotein cholesterol in patients with type 2

    Background So far, high-density lipoprotein cholesterol (HDL-C) levels and mortality were shown to have a U-shaped relationship. Additionally, high HDL-C levels increase the risk of developing a variety of diseases. However, a paucity of data exists regarding the characteristics of people with high HDL-C levels. The aim of this study was to assess the demographics and characteristics of ...

  24. Case-control vaccine effectiveness studies: Data collection, analysis

    In 2012, a group of experts met to review recent experience with case-control studies evaluating vaccine effectiveness; we summarize the recommendations of that group regarding best practices for data collection, analysis, and presentation of the results of case-control vaccine effectiveness studies. Vaccination status is the primary exposure ...

  25. Postoperative Medial Malleolar Fractures in Total Ankle Replacement Are

    There are limited data regarding risk factors associated with periprosthetic medial malleolar fractures in total ankle arthroplasty (TAA). This case-control study aimed to identify the risk factors and analyze the effect of prophylactic screw fixation in preventing a medial malleolar fracture after TAA.

  26. Epidemiology in Practice: Case-Control Studies

    Introduction. A case-control study is designed to help determine if an exposure is associated with an outcome (i.e., disease or condition of interest). In theory, the case-control study can be described simply. First, identify the cases (a group known to have the outcome) and the controls (a group known to be free of the outcome).

  27. Characterization of bacterial and viral pathogens in the respiratory

    Study design, population, and setting. This case-control study was nested within the BREATHE trial (ClinicalTrials.gov Identifier: NCT02426112, registered date: 24 April 2015) investigating whether azithromycin therapy could improve lung function and reduce the risk of exacerbations among children with HCLD [].BREATHE was a two-site, double-blinded, placebo-controlled, individually ...

  28. Correlation between the incidence of inguinal hernia and risk factors

    The incidence of recurrent hernia after radical resection of prostate cancer is high, so this article discusses the incidence and risk factors of inguinal hernia after radical resection of prostate cancer. This case control study was conducted in The First People's Hospital of Huzhou clinical data of 251 cases underwent radical resection of prostate cancer in this hospital from March 2019 to ...

  29. Services

    Deloitte's ongoing focus on research and development (R&D) is what has inspired us to carry out this survey - our first research project of this kind since the outbreak of COVID-19 in 2020.

  30. Analysis on the mechanism and dynamics of frequent debris flows in

    Debris flow is a common geological disaster in mountainous areas, which occurs frequently in the rainy season and has strong mobility and destructiveness, often bringing serious loss of life and property. Previous studies have focused more on single outbreaks of debris flow disasters, and less on multiple outbreaks of debris flow disasters in the same gully during the rainy season, which makes ...