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What to Know About Zoloft (Sertraline)

An SSRI Approved to Treat Anxiety, Depression, and Panic Disorder

Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania.

Myling / Wikimedia Commons

How Zoloft Works

Zoloft uses.

• Before Taking
• Side Effects
• Warning and Interactions

Cost of Zoloft

Alternatives to zoloft.

• How Long It Lasts

What is the most important information I should know about Zoloft?

Do not take Zoloft if:

• you are taking an MAOI, pimozide, or disulfiram; or
• you are allergic to sertraline; or
• you are taking another medication that increases serotonin levels, including other antidepressants or supplements such as St. John's wort, 5-HTP, or SAMe.

Zoloft (sertraline) is a tablet or liquid antidepressant medication that may be prescribed to treat a number of mental health disorders , including depression, premenstrual dysphoric disorder, panic disorder, obsessive-compulsive disorder, and social anxiety disorder .

Zoloft is a selective serotonin reuptake inhibitor (SSRI) that is also sold under the generic name sertraline. SSRIs prevent the reuptake of serotonin, allowing more serotonin to stay in the brain, which may improve your overall mood, sleep, and appetite while decreasing compulsive behaviors, symptoms of anxiety, and panic attacks.

Zoloft belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). As an SSRI, Zoloft blocks the reabsorption, or uptake, of serotonin in the brain, leaving more of the chemical available. Serotonin is a neurotransmitter that, among other responsibilities, helps regulate your mood, learning, and memory. In particular, serotonin is associated with positive emotions; in fact, it's sometimes called the "happy" chemical.

Zoloft has been approved by the Food and Drug Administration (FDA) to treat:

• Post-traumatic stress disorder (PTSD)
• Major depressive disorder (MDD)
• Panic disorder
• Obsessive-compulsive disorder (OCD)
• Premenstrual dysphoric disorder (PMDD)
• Social anxiety disorder

SiberianArt / Getty Images

Off-Label Uses

Although Zoloft is not specifically FDA-approved to treat these disorders, some mental health providers or doctors may prescribe it off-label for generalized anxiety disorder, bulimia nervosa, premature ejaculation, and binge eating disorder. If you are prescribed Zoloft off-label, be sure you feel comfortable with this option, and if not, request alternative treatment options, and/or more information about why your provider is prescribing this particular medication for you.

Before Taking Zoloft

When prescribing Zoloft, your treating mental health provider and/or doctor may evaluate your mental health symptoms and overall health using:

• The DSM-5 to give you an official diagnosis
• A physical evaluation and/or lab tests to rule out underlying health conditions that may be impacting or causing symptoms

Prior to prescribing Zoloft, your doctor will ask you questions about your symptoms, their intensity, and their frequency. They may also give you assessment questionnaires to complete. Depending on your specific needs, you may be prescribed Zoloft while also attending psychotherapy, or sometimes on its own.

Sertraline Vs. Zoloft

The FDA notes that both generic sertraline and Zoloft have similar efficacy when it comes to treating the mental health disorders for which it's approved. However, negative perceptions of generic medications and differing non-active ingredients can impact how each drug affects each individual.

Talk to your doctor about all medications, supplements, and vitamins that you currently take. While some drugs pose minor interaction risks, others may outright contraindicate use or prompt careful consideration as to whether the pros of treatment outweigh the cons in your case.

Precautions and Contraindications

Prior to taking Zoloft, let your doctor know:

• If you have an allergy to anything in Zoloft, including the inactive ingredients
• If you have a history of bleeding problems, seizures, liver problems, heart problems, low sodium blood levels, thyroid disorders, or glaucoma
• If you have a family history of bipolar disorder
• If you are taking an additional medication that increases serotonin levels
• If you are pregnant and which trimester you are in (third trimester is most at risk for complications)
• If you are nursing

Zoloft is contraindicated for use with monoamine oxidase inhibitors (MAOIs), pimozide, and disulfiram (when taken with liquid Zoloft). It is critical to disclose to your doctor all current and past medications (including allergy medications), your mental health history, as well as your family medical and mental health history to ensure that Zoloft is safe for you.

Populations Most At Risk

Older adults, children diagnosed with mental health disorders other than OCD, those who are pregnant or breastfeeding, and those who are taking diuretics are at greater risk for complications and may not be prescribed Zoloft.

Other SSRIs

Examples of other SSRIs used to treat similar mental health disorders include Prozac (fluoxetine) , Paxil (paroxetine) , and Lexapro (escitalopram) . These medications also work by increasing the amount of serotonin available in the brain.

Zoloft Dosage

According to Pfizer, the recommended dosage of Zoloft will vary depending on the mental health disorder.

• Major depressive disorder : The starting dosage is 50 milligrams (mg) per day with a maximum of 200 mg per day.
• Obsessive compulsive disorder : The starting dosage is 25 mg per day for those 6 to 12 years old and 50 mg per day for those 13 years old and older, with a maximum dosage of 200 mg per day.
• Panic disorder : The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
• Social anxiety disorder : The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
• Post-traumatic stress disorder : The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
• Premenstrual dysphoric disorder : The starting dosage for intermittent dosing (during the luteal phase only) is 50 mg per day with a maximum 100 mg per day. The starting dosage for continuous dosing (during the entire month) is 50 mg per day with a maximum dosage of 150 mg per day.

All listed dosages are according to the drug manufacturer. Check your prescription and talk to your doctor to make sure you are taking the right dose for you.

Modifications

Certain populations may react to Zoloft differently and may require an adjusted dosage, as well as closer monitoring by their healthcare provider.

• Zoloft is not approved for use by children under the age of 6.
• The only FDA-approved use for children ages 6 to 17 is OCD, not any other mental health disorder.
• Children 6 to 17 years old may require closer monitoring and a subsequent dosage change if during the first few months of taking Zoloft they experience significant weight loss and/or suicidal ideation.
• Pregnant and nursing individuals will need to discuss the risks and benefits of Zoloft with their doctor, as it can pose a greater risk to their fetus and newborn during the third trimester and during breastfeeding.
• It is recommended that older patients begin with dosages on the lower end to watch for adverse reactions prior to increasing their dosage if needed.

Liquid Zoloft

While many individuals opt to take Zoloft in tablet form, an oral liquid is available. If you have a latex sensitivity or allergy, you may not be able to take the liquid form as the dropper contains a natural rubber. If taking the oral liquid:

• The solution must be diluted with half a cup of water, ginger ale, lemon aid, lemon-lime soda, or orange juice.
• The dosage must be taken immediately upon dilution.

How to Take and Store

Zoloft tablets should be stored at room temperature, out of direct light, with the bottle tightly sealed. They should also be stored out of reach of children and pets.

• Zoloft can be taken with or without food.
• Zoloft should never be taken with alcohol or illegal drugs.
• When taking Zoloft, avoid grapefruit juice and eating grapefruits as it can prevent the medication from being properly metabolized.
• Zoloft should not be taken within two weeks of taking an MAOI.
• When travelling, Zoloft can be stored in your carry-on or in checked baggage, although carry-on may be the safer bet in case your luggage gets lost.

If you miss a dose of Zoloft, take it as soon as you remember, unless you are due to take your next dose soon. In other words, don't double your dosage. Keep in mind that you may experience some side effects within a few hours of your missed dosage, which may include dizziness, nausea, and feeling weak. If you have questions, be sure to reach out to your doctor.

Zoloft Overdose

If you have taken too much Zoloft (more than your typical dosage), contact your doctor right away. If they're unavailable, call Poison Control or head to the emergency room immediately.

Side Effects of Zoloft

Since Zoloft alters brain chemistry, you may be worried about how taking this medication will affect you. There's no way to predict how Zoloft will make you feel since everyone may respond differently to it. But these are the side effects to be aware of:

Common Physical Side Effects

You may experience physical side effects from taking Zoloft. These may include: 

Common Emotional Side Effects

• Nervousness
• Restlessness

Sexual Side Effects

Some of the most potentially bothersome side effects of Zoloft and other SSRIs are sexual issues. These can include reduced sexual desire or difficulty reaching orgasm, difficulty ejaculating, or less frequently the inability to maintain an erection (erectile dysfunction). These can be so distressing for some people that they may choose not to take the medication.

If taking Zoloft interferes with your sex life, speak with your prescribing physician.

• Your doctor may suggest adding a second antidepressant. Wellbutrin (bupropion) has been found to sometimes counter the sexual side effects of SSRIs.  
• Your doctor may prescribe a different medication to see if another one works better for you.
• Your doctor may adjust your dosage.
• Your doctor may want you to take the same dosage for a bit longer, as sometimes sexual side effects get better on their own. 
• Your doctor may suggest taking another medication to improve sexual function. Viagra (sildenafil), Cialis (tadalafil), or Levitra (vardenafil) are all approved by the FDA to treat sexual problems in men. Some research suggests sildenafil may also improve sexual issues in some women.  

Severe Physical Side Effects

Contact your doctor immediately if you experience any of the following:

• Allergic reaction symptoms like hives, rash, difficulty swallowing or breathing, and swelling of the face, mouth, throat, or tongue
• Difficulty sleeping
• Symptoms associated with serotonin syndrome
• Increase in bruising and/or bleeding
• Rapid heart rate

Severe Emotional Side Effects

• Increase in suicidal thoughts or attempts
• Aggression or emotional outbursts
• Increase in depressive symptoms
• Increase in panic attacks
• Extreme nervousness, irritability, or anxiety

When to Go to the Emergency Room

If you are unable to reach your doctor, head to the emergency room right away and be sure to tell them about the medication and dosage you are currently taking and when your severe symptoms began.

Zoloft Warnings and Interactions

Warnings and interactions when taking Zoloft:

• If you decide you want to stop taking Zoloft, do not quit cold turkey. Talk to your doctor first so they can help you gradually wean off of Zoloft . Quitting abruptly can cause you to potentially experience some serious sertraline withdrawal symptoms.
• Be mindful of any changes to your behavior, thoughts, and emotions, especially six to eight weeks after beginning the medication. If symptoms worsen, contact your doctor right away.
• Zoloft can increase the risk of bleeding when taken with aspirin, anticoagulants, and nonsteroidal anti-inflammatory drugs.
• Zoloft should not be taken with St. John's Wort , 5-HTP , or SAMe as these supplements can lead to serotonin syndrome.
• Illegal drugs and alcohol should not be taken while on Zoloft.
• Zoloft has a "black box warning" that, in some cases, children, teenagers, and young adults (under 25) may have increased suicidal thoughts or behavior when taking antidepressants, especially in the first few weeks after starting the drug or after the dose is changed.

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911. 

For more mental health resources, see the National Helpline Database .

Serotonin Syndrome

In rare cases, an antidepressant such as Zoloft can cause high levels of serotonin to build up in the body. This is most likely to happen to someone who's taking another medication that can elevate serotonin such as other antidepressants, certain pain or headache medications, and the herbal supplement St. John's wort.

Signs and symptoms of serotonin syndrome include anxiety, agitation, sweating, confusion, tremors, restlessness, lack of coordination, and a rapid heart rate. Seek immediate medical attention if you have any of these signs or symptoms.

Informing Your Doctor

It's important to always make sure your doctor knows which other medications, including over-the-counter medicines and supplements, you are taking.

The price you might pay for Zoloft varies with many factors such as insurance coverage, region, market, strength, and more. Consult your doctor, insurance company representative, and pharmacist to get an idea of the drug's cost to you.

Healthcare providers often must try several antidepressants before finding the most effective drugs with the least side effects for their patients. As an SSRI, Zoloft has many alternatives. These include:

• Prozac (fluoxetine)
• Cymbalta (duloxetine)
• Lexapro (escitalopram)
• Paxil (paroxetine)
• Effexor (venlafaxine)

How Long Is Zoloft Effective?

As with many other antidepressants, you can build up a tolerance to Zoloft over time, which means the same dosage becomes less effective. If you feel Zoloft isn't working as well for you anymore, consult your healthcare provider. They might change your dosage or try a different antidepressant altogether.

Singh HK, Saadabadi A. Sertraline. In:  StatPearls . StatPearls Publishing; 2021.

Desai RJ, Sarpatwari A, Dejene S, et al. Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims.   PLOS Medicine . 2019;16(3):e1002763. doi: 10.1371/journal.pmed.1002763

• Lee AJ, Chan WK, Harralson AF, Buffum J, Bui B-CC. The effects of grapefruit juice on sertraline metabolism: An in vitro and in vivo study.   Clinical Therapeutics . 1999;21(11):1890-1899. doi: 10.1016/S0149-2918(00)86737-5
• Yasin W, Ahmed SI, Gouthro RV. Does bupropion impact more than mood? A case report and review of the literature.   Cureus . 2019;11(3). doi: 10.7759/cureus.4277

Nurnberg HG, Hensley PL, Lauriello J. Sildenafil in the treatment of sexual dysfunction induced by selective serotonin reuptake inhibitors: An overview.  CNS Drugs . 2000;13(5):321-335.

AMA Journal of Ethics. Antidepressants and the FDA's black-box warning: Determining a rational public policy in the absence of sufficient evidence .

Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome . Ochsner J . 2013;13(4):533-40.

By Katharina Star, PhD Katharina Star, PhD, is an expert on anxiety and panic disorder. Dr. Star is a professional counselor, and she is trained in creative art therapies and mindfulness. 

Zoloft (Sertraline)

• Zoloft (Sertraline) Reviews

Side Effects

Interactions, what to expect, additional dosage information, secondary uses.

Sertraline is the generic form of the brand name drug Zoloft. It’s used to treat various mental health conditions, including depression, obsessive-compulsive disorder (OCD), panic attacks, post-traumatic stress disorder (PTSD), and social anxiety.

Zoloft is also prescribed to help symptoms of premenstrual dysphoric disorder, such as mood swings, bloating, irritability, and breast tenderness.

This medicine is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by boosting levels of a natural substance called serotonin in the brain.

The U.S. Food and Drug Administration (FDA) approved Zoloft in 1991.

What is  Zoloft (Sertraline)  used for?

• Obsessive Compulsive Disorder
• Panic Disorder
• Post Traumatic Stress Disorder
• Depressive Psychosis
• Premenstrual Dysphoric Disorder
• Arteriosclerotic Dementia w/ Depressive Features
• Social Anxiety Disorder
• Dementia w/ Depressive Features

What is the most important information I should know about  Zoloft (Sertraline) ?

You should not use sertraline if you are allergic to it, or if you also take pimozide. Do not use the if you take disulfiram (Antabuse). liquid form of sertraline

Sertraline is approved for use in children at least 6 years old, only to treat obsessive-compulsive disorder but not depression.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of sertraline on the baby.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop sertraline without asking your doctor.

Ask a doctor if it is safe to breastfeed while using this medicine.

Do not use sertraline if you have used an MAO inhibitor in the past 14 days. Wait at least 14 days after stopping an MAO inhibitor before you take sertraline. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with sertraline could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Your doctor will need to check your progress on a regular basis. Your family or caregivers should also watch for sudden changes in your behavior.

• an allergy or sensitivity to aspirin, tartrazine (food dye) or latex (oral solution);
• bipolar disorder (manic depression);
• heart disease, high blood pressure, or a stroke;
• liver or kidney disease;
• sexual problems;
• bleeding problems, or if you take warfarin (Coumadin, Jantoven);
• long QT syndrome; or
• low levels of sodium in your blood.

User Reviews & Rating

Overall rating for  zoloft (sertraline), what are the side effects of zoloft (sertraline) .

Get emergency medical help if you have skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat. signs of an allergic reaction:

Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Sertraline can affect growth in children. Your child's height and weight may be checked often.

Report any new or worsening symptoms to your doctor , such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• unusual bleeding or bruising;
• vision changes, eye pain, redness, or swelling;
• low blood sodium --headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or
• manic episodes --racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.
• indigestion, nausea, diarrhea, loss of appetite;
• nose bleeds;
• increased sweating;
• tiredness, sleep problems, insomnia;
• loss of bladder control;
• tremors or agitation; or
• sexual problems.

Pregnancy & Breastfeeding

Can i take  zoloft (sertraline)  if i’m pregnant or breastfeeding, what drugs and food should i avoid while taking  zoloft (sertraline) .

Drinking alcohol with this medicine can cause side effects.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Dosage Guidelines & Tips

How to take  zoloft (sertraline) .

Use  Zoloft (Sertraline)  exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take sertraline with or without food, at the same time each day.

Sertraline must be diluted with a liquid right before you take it. Read and carefully follow all mixing instructions provided with your medicine. Ask your doctor or pharmacist if you need help. liquid (oral concentrate)

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Measure the mixed medicine with the supplied syringe or the measuring device (not a kitchen spoon).

Sertraline may cause false results on a drug-screening urine test. Tell the laboratory staff that you use sertraline.

Do not stop using sertraline suddenly , or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Swallow the capsule whole and do not crush, chew, break, or open it.

Store tightly closed at room temperature, away from moisture and heat.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. take two doses at one time. Do not

Overdose Signs

What happens if i overdose on  zoloft (sertraline) .

Sertraline won’t change your personality, but it might help you feel like yourself again.

You might see your symptoms improve after one to two weeks, but it usually takes between four to six weeks before you notice the full benefits.

Some people report feeling worse during the first few weeks of treatment before they start to feel better.

Don’t stop taking sertraline without talking to your doctor first.

A typical starting dosage of Zoloft for adults is 25 milligrams (mg) or 50 mg per day. Your doctor may gradually increase your dose to a maximum of 200 mg a day.

Sertraline is sometimes used to treat other conditions, including:

• Sexual problems
• Diabetic nerve pain
• Fibromyalgia

ZOLOFT, 50 MG

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Form : film coated

Imprint : ZOLOFT, 50 MG

ZOLOFT, 100 MG

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ZOLOFT, 25 MG

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Imprint : ZOLOFT, 25 MG

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Does Zoloft Work? What Is It Like? Full Zoloft Review

Zoloft is a commonly prescribed antidepressant. If you’re wondering whether you should ask your doctor about Zoloft for depression or other conditions, or if you’ve already been prescribed Zoloft, it’s a good idea to learn about other patients’ experiences with it first.

In this article, I’ll go through a variety of Zoloft reviews to help you make a decision on whether Zoloft is right for you. I’ll focus on common Zoloft side effects, how it interacts with other drugs, and how users think it compares to other similar medications for depression and anxiety.

What Is Zoloft? What Does It Do?

Zoloft (sertraline) is a prescription-only selective serotonin reuptake inhibitor (SSRI). SSRIs work by decreasing (“inhibiting”) the re-uptake, or reabsorption, of serotonin into the brain, thus making more of it available.

Serotonin is a neurotransmitter that helps regulate mood, sexual desire, social behavior, and other necessities of everyday functioning, such as memory and sleep. Having more serotonin available in the brain allows many of those with depression and other psychiatric disorders to function more effectively.

Zoloft is used most commonly to treat depression, along with obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

Zoloft is the most commonly prescribed antidepressant in the U.S. and the second most commonly prescribed psychiatric medication. Millions of adults take it every year.

Zoloft Reviews for Depression

Many users take Zoloft for depression and report it to be effective.

Zoloft has a 7.2/10 average rating from patients using it to treat depression on Drugs.com. On WebMD, r eviewers have given Zoloft an average of 3.5/5 stars for treatment of depression. Most users who didn’t like Zoloft report side effects that outweighed the positives (we’ll get more into side effects later).

Some Zoloft reviewers, like Kitten.666 from Drugs.com, who reports that she is a 20-year-old female, claim that the medication saved their life:

“I love Zoloft! I can live again! I’m laughing and going out with friends, not laying in bed all day. I can finally breathe, my surroundings seem so much brighter, I don’t harbor hate anymore, I’m me again…More ambitious and creative like I was before I fell into this self destructive path of depression two years ago.”

Many reviewers echo this sentiment, saying that Zoloft was enough to lift them out of their depression.

While most Zoloft users report a strong positive or negative reaction to the medication, a few don’t experience much of a reaction at all, or report that it is mildly helpful in treating their depression. User cisuggs from Drugs.com offers one such Zoloft review, reporting a more manageable state of mind overall on the drug:

“Overall I definitely experienced less crying and general hopelessness on Zoloft. I still had my bad days but in general it’s manageable.”

Zoloft Reviews for Anxiety

Overall, Zoloft fares slightly better with online reviewers who use(d) the medication for anxiety-related issues, such as obsessive-compulsive disorder, social anxiety disorder, and panic disorder.

WebMD Zoloft reviewers who use Zoloft for panic disorder have given it an average of 3.87 out of 5 stars, and patients who use Zoloft for anxiety have given it an average rating of 7.7/10 on Drugs.com.

Many Zoloft reviewers report that Zoloft was helpful in curbing their panic attacks and overall sense of nervousness.

One (anonymous) WebMD reviewer, who gives Zoloft five stars on all counts, says, “Zoloft has helped me with my panic attacks and my everyday uneasiness and anxiety.”

One common problem reported by Zoloft reviewers is the medication’s tendency to increase anxiety before it begins to treat it, or to eventually stop working in curbing anxiety after initially working very well.

One Drugs.com Zoloft review describes this rollercoaster:

“I’m a 29 year old female. I’ve been suffering from horrible social anxiety disorder and panic attacks for over 2 years. I’ve been on Zoloft (technically sertraline since I’m on the generic version) for 4 months…I had little to no social anxiety anymore and almost felt like I had my life back. After 2 months I felt I plateaued. I started getting the anxiety/panicky feelings back. So I upped my dosage to 50 mg. For now it is still doing the trick but it’s nowhere near what it was in the beginning.”

A WebMD Zoloft reviewer, newts18, advises other Zoloft users to stick with the medication even if anxiety symptoms increase at first, noting that one’s reaction to the drug may shift over time:

“I started on this medication about a year ago due to panic attacks and extreme anxiety… The first week was rough, my anxiety got worse, but I stuck with it …My panic attacks have gotten less severe, and I’m able to participate in life more.”

Reviews on Zoloft Dosage

Most online Zoloft reviewers report being on an initial dose of 50 mg, which is the standard Zoloft dose.

The initial therapeutic dosage of Zoloft is 25 to 50 mg. It can be upped to 200 mg over time depending on tolerance.

The most common issue reported by Zoloft reviewers regarding dosage is that their reaction to the drug plateaus over time, requiring their doctor to increase their dosage in order to be effective. Some reviewers even report having to switch medications eventually once they increased their Zoloft dosage as much as possible.

For example, one Drugs.com Zoloft reviewer, MaryKrazy1, writes:

“Zoloft worked AWESOME for my extreme anxiety and major depression. It worked for many years but eventually (as all good things do), it stopped working as well and once my dosage couldn’t go any higher, I had to start the whole process of finding the right medication and the right ‘cocktail’ for me.”

Other Zoloft reviewers warn against starting with a high dose of Zoloft, noting that it can increase negative side effects, such as weight gain and a loss of libido. Ricardo7171, a WebMD Zoloft reviewer, says that he switched to a lower dose of Zoloft for this very reason:

“The one negative was the sexual side effects at the higher dose. Fortunately, at 25 mg, I have none of these issues.”

Reviews on Zoloft Side Effects and Drug Interactions

Zoloft users frequently report that the first week to four weeks on Zoloft produced many negative side effects, such as flulike symptoms, racing thoughts, increased anxiety, insomnia, gastrointestinal issues such as diarrhea and constipation, night sweats/terrors/nightmares, tremors, nausea, fatigue, muscle pain, apathy, and irritability.

However, most of these users say that the initial side effects did subside once their body adjusted to Zoloft.

A 27-year-old male Zoloft user reports in a review on Iodine.com, “In the beginning you will feel terrible. Flu-like is the best way for me to describe it. Tightness in the jaw, no appetite, and stomach issues when you begin to eat. Diarrhea and constipation.”

A 17-year-old man who took Zoloft for OCD agreed that the first weeks on Zoloft resulted in negative side effects, writing on Iodine.com, “Potential for increased anxiety at first. Also caused severe insomnia for a few weeks.”

A 27-year-old female patient, also writing a review on Iodine.com, concurred: “Take vitamins; the adjustment period causes muscle fatigue. Crazy vivid nightmares are normal too.”

Most Zoloft reviewers offer light at the end of the tunnel if you’re willing to stick through the initial side effects, though.

One Zoloft review on Everyday Health states , “The side effects at first were horrible – headaches, nausea, dizziness; had to leave work one day because of them. After a week the side effects had eased and after a month they were gone.”

While most of the negative side effects of Zoloft seem to be manageable and temporary, some of them are more serious. Some Zoloft users report worsened anxiety or depression and even suicidal thoughts and behaviors.

Read this account from a Zoloft user at Everyday Health:

“I went in for anxiety and slight OCD issues, as well as light depression…As I took this my depression got worse and worse, and I began a self harm addiction…I honestly believe Zoloft not only did nothing for my anxiety and slight OCD, but made my small depression issue into a monster. I would never take this again.”

Other serious side effects reported by Zoloft reviewers include racing heart, heart palpitations, and increased blood pressure.

Loves to read, one Zoloft reviewer, writes of their experience with these side effects on Drugs.com:  “I went to my Doctor and asked for medication for general anxiety and depression. I was prescribed Zoloft. I took it with a meal and about two [hours] later, I felt like I was having a heart attack as I had chest pain, racing pulse and palpitations. And I took my Blood Pressure and it was 140/90, Pulse 110. My usual Blood Pressure is 106/70, pulse 75.”

Other serious side effects that Zoloft reviewers mention include extreme withdrawal symptoms and difficulty coming off the drug. If you take Zoloft or are taking Zoloft and experience these or any other negative side effects, contact your doctor or 911 to make sure you’re safe.

Zoloft Reviews: How Does It Compare to Other Medications?

One of the most common questions that Zoloft users and potential users have is how Zoloft compares to other SSRIs and other psychiatric medications. Let’s take a look at some user reviews from patients who have taken both Zoloft and other antidepressants to see how it stacks up.

Many Zoloft reviews describe Zoloft as the first antidepressant that worked.

WebMD reviewer MKRPK says, “Zoloft makes me cheerful, relaxed, undepressed, not anxious. I have switched between it and other antidepressants many times over many years, trying to find the best combo of benefits and least side effects. I keep going back to it.”

Drugs.com Zoloft reviewer Kitten.77 agrees: “I have tried several antidepressants, but nothing seemed to work. However, I started Zoloft about a week ago, and I am officially sold on it. It makes me feel more optimistic about life.”

Take note that if you are switching from one antidepressant to another, you should let your doctor know ahead of time, and do so carefully.

Sc00bs, a Zoloft reviewer on Drugs.com, warns readers, “Was switching from 40mg of Celexa [citalopram, another SSRI] to 100mg of Zoloft. Felt great first two weeks. Then it was pure hell after that. I ended up with Serotonin syndrome during the switch.”

Serotonin syndrome is a collection of dangerous symptoms, including increased body temperature, irritability, aggression, tremors, diarrhea, and heightened reflexes, that can occur if you switch antidepressants, add a new drug to your medication regimen, or increase your dosage of a psychiatric medication.

Several other Zoloft reviewers have reported similar experiences when attempting to find the right medication to treat their depression.

Finally, if you or your doctor think you may have a mood disorder such as bipolar disorder rather than or in addition to depression, Zoloft reviewers warn against using Zoloft and other SSRIs, as they can worsen your symptoms.

TWG74, a Zoloft reviewer on Drugs.com, says, “I was prescribed this medicine in 2004 to help with depression. Instead of getting better I progressively got worse and my psychiatrist’s answer was to put me on Xanax. Long story short, I ended up in a psychiatric hospital. Turns out I have bipolar II and since I wasn’t on a mood stabilizer I essentially lost my mind. Horrible experience.”

Several other reviewers who have since been diagnosed with mood disorders report negative experiences taking Zoloft. Make sure that you check in regularly with your doctor if you start taking Zoloft, keep track of your side effects, and don’t be afraid to change medications (under the advice of a medical professional) if Zoloft isn’t working for you.

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Cymbalta vs. Lexapro for Depression: Which Is Better?

Key differences between cymbalta and lexapro.

• How Do They Work?

Which Is More Effective for Depression?

• Side Effects

Drug Interactions

Choosing between cymbalta and lexapro.

Cymbalta (duloxetine) and Lexapro (escitalopram) are antidepressant medications. Though these two medications have some similarities, there are a few key differences.

Read on to learn more about the similarities and differences between Lexapro and Cymbalta and why a healthcare provider may recommend one of these medications over the other to treat depression.

Getty Images / Bloomberg  / Contributor

Cymbalta and Lexapro are alike and different in many ways. Both are commonly taken to treat depression and anxiety disorders. But Cymbalta is approved to treat other conditions as well.

They also belong to different drug classes, have slightly different mechanisms of action, and may cause different side effects.

Lexapro is a brand-name drug also known by its generic name: escitalopram. It belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs).

Cymbalta, on the other hand, is a brand-name medication also known as duloxetine. It belongs to the serotonin-norepinephrine reuptake inhibitor (SNRI) drug class.

The table below compares key facts about the two medications.

What Are Cymbalta and Lexapro's Uses?

The U.S. Food and Drug Administration (FDA) has approved Lexapro and Cymbalta to treat depression and anxiety. However, Cymbalta has been approved for other uses as well.

Specifically, the FDA approved Lexapro to treat:

• Depression, medically known as major depressive disorder (MDD) , in adults and children ages 12 years and older
• Generalized anxiety disorder (GAD) in adults and children ages 7 years and older

Cymbalta’s FDA-approved uses include:

• MDD in adults 
• GAD in adults and children ages 7 years and older
• Pain caused by diabetic peripheral neuropathy in adults 
• Fibromyalgia  in adults and children ages 13 years or older
• Chronic (long-term) musculoskeletal pain in adults

SSRIs vs. SNRIs: How Do They Work?

All antidepressants work to regulate mood by affecting certain chemicals in the brain, but the exact mechanism of how they work varies by drug class.

Serotonin and norepinephrine are neurotransmitters. Neurotransmitters are chemicals that help neurons (nerve cells) communicate. These neurotransmitters perform key roles in regulating mood, behavior, sleep, and more.

When someone has depression, it may be due to a chemical imbalance in their brain. Without a sufficient amount of serotonin and/or norepinephrine available, neurons may not communicate effectively, leading to difficulty regulating mood and mental health changes.

SSRIs, including Lexapro, work by blocking the reabsorption (reuptake) of serotonin in the brain, making more serotonin available to transmit messages between neurons. This helps to enhance serotonin levels and improve communication between brain cells, which can positively affect mood.

All SSRIs have the same mechanism, but a person may have a better response to one SSRI than another. Other examples of other SSRIs include:

• Celexa (citalopram)
• Prozac (fluoxetine)
• Zoloft (sertraline)

SNRIs, such as Cymbalta, have a similar mechanism but target two neurotransmitters instead of one.

By binding to specific receptors on neurons, SNRIs block serotonin and norepinephrine reuptake, allowing more of these neurotransmitters to stay active in the brain. This helps to improve communication between nerve cells and may help to ease symptoms of depression or anxiety.

All SNRIs work this way. However, same as it is with SSRIs, some people may respond better to one SNRI than another. Examples of other SNRIs include: 

• Effexor XR (venlafaxine)
• Fetzima (levomilnacipran)
• Pristiq (desvenlafaxine)

SSRIs and SNRIs take a couple of weeks to start working, and dose adjustments are often necessary. It’s important to follow up with your prescriber to discuss any changes in your symptoms or dosage.

Is Cymbalta or Lexapro better? This question can be tricky to answer because each person may respond differently to each medication.

However, clinical trials provide some information that helps compare the two medications regarding how well they work for treating depression. 

Researchers measure the effectiveness of an antidepressant in clinical trials with various assessment metrics, such as symptom rating scales.

What Is a Symptom Rating Scale?

A symptom rating scale is an assessment measurement system for rating symptoms before treatment begins. It’s repeated after the participants have taken medication (or placebo) for a certain length of time. One such measurement tool is the Hamilton Rating Scale for Depression (HRSD).

In separate clinical trials, Cymbalta and Lexapro were similarly effective in reducing depression symptoms when compared to a placebo.

Compared to a placebo, taking Cymbalta led to a 10- to 12-point improvement on a depression rating scale after two months of treatment. Similarly, taking Lexapro resulted in a reduction of 12 points compared to placebo after two months.

A head-to-head clinical trial is a better way to measure the relative effectiveness of two medications. A few trials have compared Cymbalta and Lexapro for MDD. Here’s what these studies found:

• One trial compared Cymbalta and Lexapro for MDD. After eight weeks, participants who took Lexapro had a greater reduction in depression symptoms compared to those who took Cymbalta.
• Another study compared Cymbalta and Lexapro over an eight-month period. In this study, both medications led to similar improvements in depression symptoms. The only notable difference in the results was that Lexapro was better at improving sleep-related symptoms.

Meta-analysis is another tool that can help researchers draw conclusions based on data from multiple individual studies.

A 2018 meta-analysis reviewed various studies of Cymbalta and Lexapro to compare the two medications. Overall, the results suggest that Cymbalta and Lexapro are similarly effective in reducing depression symptoms.

Ultimately, Lexapro and Cymbalta are similarly effective for treating depression. However, individual results can vary.

If one of these medications does not work well, trying the other remains an option. The decision to stay on a particular antidepressant versus switching to a different one often boils down to how well a person tolerates the medication.

Side Effects of Cymbalta vs. Lexapro: Which Is More Tolerable?

Most people can take Cymbalta or Lexapro without having side effects, and if they occur, they’re usually temporary or mild.

Because these medications work similarly in the body, they share many of the same potential side effects.

Mild side effects that are common for Cymbalta and Lexapro include:

• Increased sweating
• Sexual side effects, such as erectile dysfunction , trouble reaching orgasm, or decreased libido

Some mild side effects are unique to one medication. Taking Cymbalta may also result in dry mouth , constipation , and decreased appetite. Those taking Lexapro may experience insomnia or fatigue.

Based on comparative studies, Lexapro is generally a better-tolerated medication and causes fewer side effects than Cymbalta. In head-to-head trials and other studies, more participants stopped taking Cymbalta because of side effects than those who were taking Lexapro.

Though rare, taking either Cymbalta or Lexapro may result in severe side effects. Examples include:

• Serotonin syndrome , a dangerous reaction caused by an excess amount of serotonin in the body 
• Increased risk of bleeding
• Impaired ability to operate machinery or vehicles
• Angle-closure glaucoma , an eye condition
• Hypersensitivity , or severe allergic reaction
• Dangerously low sodium levels

Taking Cymbalta may result in additional potentially severe side effects. These include:

• Liver damage
• Impaired blood sugar control
• Low blood pressure when standing up , leading to falls
• Increased blood pressure

Additionally, both Cymbalta and Lexapro carry a boxed warning , the most serious warning the FDA provides.

This warning speaks to the increased risk of suicidal thoughts and behaviors that either medication may cause in children or young adults. They encourage close monitoring for individuals who are starting either Cymbalta or Lexapro for any worsening or emerging suicidal thoughts or behaviors.

Lexapro and Cymbalta interact with many other medications. These interactions may limit the medications' effectiveness or raise the risk of side effects.

Cymbalta and Lexapro should not be taken with monoamine oxidase inhibitors (MAOIs) , which means they should not be taken at the same time or within 14 days of each other. MAOIs include Marplan (isocarboxazid), Zyvox (linezolid), and methylene blue. Taking MAOIs with antidepressants may dangerously increase the risk of serotonin syndrome.

Though less severe, some other medications may interact with both Lexapro and Cymbalta, such as:

• Antiplatelets or anticoagulants, such as Jantoven (warfarin) or aspirin, may result in an increased risk of bleeding.
• Other medication classes that increase serotonin because these can increase the risk of serotonin syndrome. Examples include triptans such as Imitrex (sumatriptan), tricyclic antidepressants like amitriptyline , and certain opioids, such as methadone .

Some additional medications interact with Cymbalta but not Lexapro. Examples include:

• Medications that inhibit (block) certain liver enzymes, such as Cipro (ciprofloxacin), Tagamet (cimetidine), and Luvox (fluvoxamine). These interactions may lower Cymbalta's effectiveness.
• Antacids like calcium carbonate or Maalox. These prevent the body from absorbing Cymbalta effectively and potentially lower its effectiveness.

This is not a complete list of medications that may interact with Cymbalta or Lexapro. Before combining medications, check with a healthcare professional or pharmacist.

Several factors are important to consider when deciding between Cymbalta and Lexapro.

Though both are similarly effective for treating depression in some people, others may not find the same success. If one of these drugs does not offer improvement, trying the other medication may work.

Another important consideration is side effects. Some studies suggest that Lexapro provides effective treatment with more tolerable side effects. Therefore, considering potential side effects is essential when selecting one of these medications.

Talking with a healthcare provider will work best when selecting one of these medications. This professional will understand your health background and what key factors they should address to ensure safe and effective care with either Cymbalta or Lexapro.

Help Is Available

If you or someone you know is having suicidal thoughts, dial  988  to contact the  988 Suicide & Crisis Lifeline  and connect with a trained counselor.

For more mental health resources, see our  National Helpline Database .

Lexapro and Cymbalta are two antidepressants commonly taken to manage depression and anxiety. Lexapro belongs to the SSRI drug class, while Cymbalta is part of the SNRI class of medications.

Clinical trials suggest these medications are similarly effective, but individual responses may vary. 

Though both drugs may commonly cause side effects like nausea and sexual dysfunction, Cymbalta tends to have more side effects compared to Lexapro. Both medications can interact with various medications, but Cymbalta's interactions may more significantly interfere with its effectiveness. 

When choosing between the two medications, your healthcare provider should consider factors such as individual response, side effect profiles, and interactions.

National Institutes of Health DailyMed. Label: Lexapro- escitalopram tablet, film coated .

National Institutes of Health DailyMed. Label: Cymbalta- duloxetine hydrochloride capsule, delayed release .

New Frontiers Psychiatric & TMS. Neurotransmitters involved in depression . December 5, 2023.

Khan A, Bose A, Alexopoulos GS, et al. Double-blind comparison of escitalopram and duloxetine in the acute treatment of major depressive disorder . Clin Drug Invest. 2007;27:481-492. doi:10.2165/00044011-200727070-00005

Pigott TA, Prakash A, Arnold LM, et al. Duloxetine versus escitalopram and placebo: an 8-month, double-blind trial in patients with major depressive disorder . Curr Med Res Opin. 2007;23(6):1303-1318. doi:10.1185/030079907X188107.

Maneeton B, Maneeton N, Likhitsathian S, et al. Escitalopram vs duloxetine in acute treatment of major depressive disorder: meta-analysis and systematic review . Neuropsychiatr Dis Treat. 2018;14:1953-1961. doi:10.2147/NDT.S152410.

By Patricia Weiser, PharmD Patricia Weiser, PharmD, is a licensed pharmacist and freelance medical writer. She has more than 14 years of professional experience.

Is It Time to Switch from Zoloft to Prozac? How to Tell

Posted: May 15, 2024 | Last updated: May 15, 2024

Switching from Zoloft to Prozac: What to Expect

Dealing with  depression  can feel overwhelming, whether you’re deep in a two-week funk or have been enduring it for years. And while depression is a mental health condition that looks different for everyone, it’s more common than you probably think — about  21 million  American adults experienced a depressive episode in the last year. 

Sure, that statistic might seem a little grim at first glance, but there’s a light at the end of the tunnel.

Whether you have major depressive disorder (MDD) or seasonal affective disorder (SAD), depression is very treatable. One of the most effective treatments for depression — as well as  anxiety disorders  — is medication. This includes  Zoloft  (which  contains   sertraline  as the active ingredient) and  Prozac  (which  contains   fluoxetine  as its active ingredient).

When it comes to antidepressant medication like Zoloft and Prozac, what works best for you may not work for someone else, and vice versa.

If a healthcare provider diagnoses you with depression, you might need to try several types of  antidepressants  — potentially at different doses — until you find the right fit (just like Goldilocks).

For instance, you might start off taking Zoloft but eventually switch to Prozac because its side effects feel less severe. Whatever the reason, switching from one medication to another is totally normal.

That said, if you’re thinking about changing from Zoloft to Prozac — two of the most popular medication options for depression —  the process can be a little confusing. When is the right time to make the big switch? What are the risks? How do you go about it safely?

Of course, you should always consult a healthcare provider for medical advice before making any changes to your medication. But we’ll run through these questions and offer more insight into the process so you’re armed with the preliminary info. 

Zoloft (Sertraline) and Prozac (Fluoxetine): An Overview

Let’s start with the basics:  Zoloft and Prozac  belong to a category of antidepressants called  SSRIs , or selective serotonin reuptake inhibitors. They do their job  by  targeting a neurotransmitter called serotonin, also known as the “happy hormone.” 

Because of their effectiveness, both Zoloft and Prozac are considered first-line treatments for treating depression, as well as certain  anxiety disorders . In addition to having the official seal of approval from the U.S. Food and Drug Administration for treating depression, both meds are FDA-approved to  treat obsessive-compulsive disorder  (OCD) and  panic disorder . 

Their differences? Zoloft can be  used  to help people with post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and  social anxiety  disorder. Prozac, on the other hand, can be  used  as a treatment for bulimia nervosa. 

Common Reasons for Switching from Zoloft to Prozac

You might be thinking,  These medications sound pretty similar — why would someone want to switch in the first place? 

It may seem confusing, given that Zoloft and Prozac share many similarities. This includes overlapping with certain common side effects, like: 

Diarrhea and dyspepsia (indigestion) 

Decreased libido

Abnormal ejaculation

There are several other potential side effects that could be cause by both medications, but some of these side effects may be more likely or more severe depending on whether you're taking Zoloft or Prozac.

That said, you might switch from Zoloft to Prozac because: 

The medication simply isn’t working for you. It may take several weeks or even a couple of months for your body to fully feel the effects of either medication, but even then, you still might not feel improvement after taking it. A  2015 study  found that one-third of individuals with depression have treatment-resistant depression, or TRD, meaning their depression doesn’t necessarily improve with initial treatment.

The side effects are too severe. From weight gain to difficulty sleeping, even a low dose of medication can have side effects. If they’re too intense or making you feel worse, you might want to consider switching. 

As always, if your side effects persist or you have concerns, reach out to your healthcare provider.

Side Effects of Switching Zoloft to Prozac

Not only are there specific side effects associated with each individual medication, but there are also potential side effects that come with switching from Zoloft to Prozac. 

One of the biggest side effects to be aware of is  antidepressant withdrawal . This can happen to folks who decide to discontinue using their medication abruptly. In fact, roughly  one in five  people will experience withdrawal when they suddenly stop taking their antidepressants or change the dosage. 

Just as it takes time for your brain to gradually adjust to a new medication, it takes time to adjust to  not  taking it. If you suddenly  stop taking Zoloft , for example, it  could result  in discontinuation symptoms or even a relapse in your anxiety or depression. The same applies if you were to  stop taking Prozac . 

For both Zoloft and Prozac, withdrawal symptoms can include: 

Mood changes

Irritability

How severe the symptoms are and how long they last are dependent upon the person. The bottom line? Quitting your meds without a game plan is never a good idea.

Below, we’ll outline the steps you should take instead. 

How to Switch Medications Safely

If you’re considering switching medications, it’s important to do so responsibly and under the guidance of a healthcare provider.

Depending on the antidepressant, it can be safe to  switch immediately  (also called a “direct switch”) to a replacement. But when it comes to transitioning  from  Zoloft to Prozac, tapering is the recommended technique.

Tapering involves slowly reducing your dosage of Zoloft until you stop taking it altogether. The process of tapering usually involves lowering your dosage every couple of days over the course of several weeks.

Tapering off your meds might last longer or be shorter based on what your provider recommends and your tolerability. Once the sertraline is no longer in your system, your provider will likely have you start taking Prozac at a dosage that works for your unique needs.

Cross-tapering is another technique where you gradually decrease the dosage of your current medication while simultaneously increasing the dosage of your new medication. 

Switching antidepressants  isn’t as complicated as it may seem. Still, it’s crucial to listen to your healthcare provider to lower your chances of  experiencing

https://www.ccjm.org/content/89/1/18

If you’re curious about switching from Prozac to a new medication — like  escitalopram  (Lexapro),  paroxetine  (Paxil),  citalopram  (Celexa or Cipramil)

or fluvoxamine (Luvox or Faverin) — our  guide to antidepressant options  can help you figure out which one is best for your needs.

Switching From Zoloft to Prozac: Final Thoughts

Thinking about swapping out your current  medication  for a new antidepressant is a big decision — but you don’t have to do it alone. With the help of your healthcare provider — be it a primary care provider or a psychiatrist — you can come up with the best plan for your specific needs and mental health.

In the meantime, there are plenty of other ways to build up your mental health in addition to medication. This can include: 

Opening up to a loved one.  Talking about your struggles with a loved one not only normalizes them but also lets others know you need support — and there’s nothing wrong with that. The people who care about you the most want to show up for you in the best way possible, and letting them in — even if it’s a little scary — is the first step.

Therapy.  Therapy  is one of the most effective strategies for dealing with depression and anxiety. From  cognitive behavioral therapy  (CBT) to psychotherapy (or  talk therapy ), there’s a wide range of options to explore. If you don’t feel like meeting with someone in-person, online therapy is a super convenient alternative for connecting with a mental health professional.

Practicing self-care.   Self-care  looks different to everyone, but it’s ultimately about prioritizing your needs, which includes your mental health. For some, self-care means getting enough rest,  breaking a sweat  at the gym or taking time to  journal  in the morning. For others, it’s scheduling post-work margaritas with friends. The best part? It’s up to you.

Still feeling stuck? Our  mental health services  are always available with resources to point you in the right direction.

This article originally appeared on Hers.com  and was syndicated by MediaFeed.org .

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Zoloft for Social Anxiety Disorder User Reviews

Zoloft has an average rating of 7.3 out of 10 from a total of 281 reviews for the treatment of Social Anxiety Disorder. 66% of reviewers reported a positive experience, while 19% reported a negative experience.

Zoloft rating summary

281 ratings from 299 user reviews.

Compare all 10 medications used in the treatment of Social Anxiety Disorder .

Reviews for Zoloft

• Top reviews
• Most recent
• Most helpful
• High rating
• Time on medication
• Taken for 1 to 6 months
• January 12, 2017

"Half the reviews on here are a load of garbage. They range from 'the side effects are too awful' to 'It gives me more anxiety.' Do yourself a favor and do not read to any review from anyone who has taken this drug for less than 8 weeks. If you are serious about reducing your anxiety, then grow some balls and give Zoloft time to work. Yes, you're going to have a number of side effects in the beginning, ranging from drowsiness, nausea, sexual dysfunction, loss of appetite, and even increased anxiety. Guess what, nearly all of these are going to disappear after the first two weeks. In fact, all of the side effects disappeared for me, and it wasn't until around week 8 that I felt the glorious power of this drug. GIVE IT TIME."

• Taken for less than 1 month
• June 5, 2020

"I have GAD. I knew I was needing support emotionally. 15 years ago, I had used Zoloft and it worked well, so I asked my doctor if I could use it again. So I started on 25mg and after 2 weeks, I upped to the 50 mg my doctor prescribed. Honestly, week 3 and 4 were the worst for me because I couldn't eat, and I felt so much worse with anxiety and lack of peace of mind. Because I was working from home, and others mentioned that the first month was bad, I felt like I was being pushed under emotionally. I had to do a lot of self-talk like 'I am not my feelings, this will pass,' etc. I took my Zoloft at night, and it seemed by evening, I always felt better, but mornings were so difficult. But right at the end of week four, a cloud lifted, and I felt peaceful and calm. So I appreciate others sharing their experience because that's exactly what happened to me. And I pushed through it, and I'm glad I did because I feel much better. Hope that helps someone in week 3. It does get better. Hang in there."

• Taken for 6 months to 1 year
• August 25, 2020

"So far so good :) I used to have anxiety attacks over little things like answering the phone or job interviews and definitely missed out on a lot of my college experience because my social anxiety was so bad. I’ve been on Zoloft for about 8 months now for GAD as well as social anxiety and I can say I feel almost like a new person. I now don’t fear going places like the bank or gas station alone. The thought of having to call someone I don’t know on the phone is easy breezy and I now have a job which involves me talking to customers all day, it’s truly amazing!!!! Give it time to work, but remember everyone’s different so don’t be discouraged :)"

Frequently asked questions

• How long does Zoloft (sertraline) withdrawal last?
• How long does Zoloft (sertraline) take to work?
• Does Zoloft (sertraline) cause weight gain?
• How long for an increased dose of Zoloft to work?
• February 24, 2020

"I was in a really bad place. I have had social anxiety most of my life due to trauma in my early life. After experimenting with LSD and having children, my symptoms worsened dramatically. I started therapy and after a year, I wasn't getting any better. My Dr. suggested Zoloft because along with anxiety, I had a lot of symptoms of PTSD. I felt it right away. I started at 25mg, then up to 50mg, and now I am at 100mg. I am a person that couldn't make phone calls, wouldn't leave the house alone, and I am at 0% anxiety. My mind is clear for the first time in years. Someone else used the term fearless and said they could tell people things they never would before. I kind of feel that way as well. I had side effects each time I raised the dose, but they went away after about 2 weeks each time. It was a little rough at first, but I hung in and the last few months have been some of the best of my life."

• June 3, 2021

"When I say Zoloft changed my life, I mean Zoloft not only changed but SAVED my life. It is the quickest acting medication for anxiety I have ever been on, along with being the one with the least side effects. I was having such awful anxiety that it was crippling me and making it unbearable to live. I started taking Zoloft (50mg) and that worked for me but I still had an anxiety attack here and there, upped to 75mg and it has completely changed my life for the better. My body feels calm and at peace."

Are you taking this medicine?

• Add your review
• Learn more about Zoloft
• May 15, 2017

"I have dealt with ups and downs, anxiety, social anxiety, depression, etc. for years. My life overall is normal and I managed the episodes, but I always knew they were there and didn't like feeling that way. I am married, we have children, combine that with everything else, and at times it was just too much. The doctor suggested Zoloft. I was nervous at first and really didn't know what to expect. In fact, I waited a month or two to even fill the prescription. The side effects were obvious at first: dizziness, tiredness, minor confusion. I don't want to scare anyone because I still functioned. I was still able to work, take care of the kids, everything was pretty much normal, but I could tell my mind was a bit off. After about a month, the side effects faded away. After two months, my mind became clear, and my attitude towards life improved dramatically. Little things didn't bother me anymore. I started working out, and that didn't bother me anymore. My wife would argue with me about normal marriage stuff, but I wouldn't yell back. In fact, I was able to see how foolish most of the fighting was and how pointless it was to yell back. My work life improved, my conversations with other people improved. I found myself more interested in what the person was saying and focusing more on what they were saying. At a follow-up visit with my doctor, he asked if I'd like to stay on the medication. I told him that my life has never been better and my mind never more clear, so why would I choose to stop. He agreed and was happy with my progress. He initially prescribed 100 mg, but I found 50 works well for me at this point. So, every night before bed, I take my pill and wake up the next morning feeling ready to go instead of wanting to stay in bed. For those just starting or thinking about starting this medication, I can honestly tell you it has changed my life for the better. Initially it was rough, but after a while all that fades, and you're left feeling really good. For me, it took about two months; for others, it may take longer or shorter. I hope this helps as I read a lot about this medication prior to starting and found a lot of the write-ups were negative. I honestly think those people may have other issues or conditions that this medication can't help, or they may have not been able to get through the initial break-in period."

• Taken for 1 to 2 years
• April 28, 2016

"33 y/o female, 5'5, 125 lbs, 200 mg/day, 1 1/2 years and will continue indefinitely. Pros: social anxiety gone. Unbelievable. Able to start spontaneous conversations with 'strangers', now able to develop and share deep, intimate friendships. Not hyper self-conscious anymore. I joke around and enjoy making people laugh. Sexually uninhibited (with my husband) - seriously, the best sex I've ever had, I'm not self-conscious at all anymore and I have no problems with orgasm - actually the opposite (best. ever.) Weight loss, 25-30 lbs, and I feel light, energetic and happy with my body now. Food! I used to be a horribly picky eater my entire life, now I try new foods without a second thought and enjoy them! Zoloft has changed my life."

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• December 21, 2020

"some of the reason people complain about zoloft/sertraline and say it doesn't work? 3 reasons: - They didn't increase dosage when it wasn't working - They took it for too short time - They got prescribed drug, that doesn't fit them or their illness I suffered from social anxiety disorder since childhood and for me zoloft started working after more than 1 MONTH, and after 3x increased dosage than at the beginning. When did I know it had started working? It was like a switch, from day to day. I just was this feeling that now I don't have this "everyone is watching and judging me". I still have it sometimes and that's why I'm in psychoterapy (which is also very helpful), but Zoloft changed my life maybe not totally, but it definitely helps but PLEASE GIVE IT SOME TIME, if something doesn't work for 2 weeks, DON'T GIVE UP and increase dosage. If drug doesn't work then increase the dose again, if it doesn't working after 2 months, just ask your doctor for another drug, keep trying and DON'T GIVE UP."

• November 3, 2019

"On Zoloft for Generalized Anxiety Disorder. The first few weeks were honestly so bad. I had such bad brain fog, more anxiety, depression, wanted to sleep all the time, etc. I couldn’t eat and lost about 7 pounds within a few weeks. Things were not looking good but I pushed through it. One morning I woke up and my life had been changed. I found out what it was like to feel like everything would be okay. I am so happy I take this medicine and I recommend it for anxiety if you’re willing to push through the beginning. I have a new view on life and it feels so good."

• September 8, 2019

"I feel so obligated to leave a review. I was sitting where you are now almost 4 weeks ago. I was terrified after reading the reviews, however I knew I needed help. I had postpartum depression and let it go unchecked for a long time. When that seemed to subside, I was hit with debilitating anxiety that really started to rob me of my life. I had severe insomnia as a result. I started on 25mg for a week, then went up to 50mg where I am currently at now. It was a very difficult med to get on. I had increased anxiety, panic, still fought insomnia. After about two and half weeks and help from my family, I felt like the world felt brighter. Everyday since has been getting better. I can’t tell you enough that if you can weather the first 2-3 weeks, you will not regret it. I am getting back to my old self and it feels so good. I am so thankful, and feeling so blessed. You got this!"

• February 23, 2020

"I was very anxious and used to overanalyse everything. Now I am confident and do not really care much of what people might think. This medication made me also a lot more happier, I've started it for about 5 month now and I've never been as confident and rooted as now."

• February 10, 2020

"I am in my 40s & I suffered a panic attack for the first time while driving. My friend said try Zoloft, so I saw the doctor for it. I kept a log first entry dated May 1, 2018. Day 1 on zoloft: "I felt tired, little dizzy, brain fog - woke up a couple of times feeling weird, not myself. I had stomach upset and diarrhea." Day 2: "I woke up feeling like a zombie. I was very tired, no emotion, but I had to get up, when I was driving & came to a stop light, I felt very anxious." "I hope I'm making the right decision to start meds but do I have a choice???" Day 3 & 4: "...felt tired & having a brain fog. My stomach is rumbling & little nausea but it is manageable." Day 8: "I woke up feeling tired and right now I feel a little anxiety" Day 17: "It's been over 2 weeks & I am driving with little to no anxiety!" I have been on Zoloft 25 mg for 2 years now. Because of reading other people's reviews, I knew what to expect & that kept me going!"

• August 18, 2019

"This Zoloft is life changing stuff for my social anxiety. I tried the counselling, CBT, hypnosis,etc. I take these and a week later my critical anxious voice has disappeared. My social anxiety that has ruined my life gone from a 10 to a 2. Wow."

• June 7, 2020

"I don't see why some say: "I don't recommend this medication." Why dont you? Tell us plz: the dosage, other medications you are taking, age, etc. I am wanting to start zoloft but when I read these reviews I don't know what is better, having these panic attacks or trying zoloft. Every body is unique so it would be a great help if any one would give a better description of their situation. I thank all those who gave a great explanation of their situation."

• December 12, 2014

"Asking my doctor about Zoloft was one of the best decisions for me. I have suffered from anxiety as long as I can remember. I feel like a new person now. I didn't even fully realize how bad it was until taking Zoloft. I didn't want to take meds; I thought my anxiety was just part of who I was and something I would have to deal with forever. Zoloft has changed my life."

• December 26, 2019

"I started taking this for anxiety and have noticed a huge boost to my mood that I didn't expect. I went from feeling sad all the time to feeling amazing. Anxiety doesn't bother me and I feel happy for the first time in my life."

• June 2, 2020

"I started with Zoloft for GAD and derealization. I started with 25mg for one week and then I upped on 50mg, but the side effects were too bad so I went down on 25mg. My God was the beginning terrible! Anxiety was soo much worse, feeling terrified, depressed, feeling guilt, crying, brain fog and nausea. I lost almost 8kg in 2 weeks because I couldn't eat. My Psychiatrist told me to take 0.5mg of Clonazepam till the side effects lift. After exactly 4 weeks I can say that all the side effects are gone. I feel a bit sleepy, but I am much more calm, no anxiety at all, no guilty feeling. Derealization is still here but much less, I don't care about her so she will go away with time too. I went back on work and started socalizing again. I take only 1/8 of Clonazepam. I will up my dose in a few days, but slowly. I PROMISE you that the starting side effects will pass. Trust me! I know how hard it is. This is a reminder for me too if the upping bring back the side effects."

• May 31, 2019

"I started taking this drug 50mg for social anxiety and depression and this has truly been amazing. At first reading some of the negative reviews and not focusing on the positive one I was nervous about trying it, but enough was enough. For the first few weeks yeah there were some side effects but they were not as severe as I thought. They went away after about a month. What this drug will do is meet you half way and provides a better outlook on things. Do I still have anxiety at times, of course, but its no where near what it used to be. This drug will meet you half way. Its nice going out in public and interacting with people, I didn't realize how normal it was. The meds work, but you have to want to change for you to really notice it. Hope this helps ya'll."

• August 23, 2013

"Have struggled all my life with anxiety, worked out 7 days a week to try and control it. Panic attacks—just horrible—no lifts, no planes, no tunnels. Tried CBT, finally I thought I don't want to live this way anymore. Pill-phobic, but finally I tried it, a quarter of a tablet for two weeks, then half again for two weeks. What can I say? It has changed my life completely. I love it. I feel normal! No side effects. It took three months but felt better within weeks. All of you out there undecided, unsure, afraid of what you've read—please do yourself a favor and try it—be positive about it, open and give it a go—you won't regret it. I can fly, drive, amazing."

• March 20, 2015

"Headaches and a little nausea at the start, now 4 months in, I don't know how I coped before. The anxious "bad butterflies" that I thought were normal, have gone away. Obsessive over thinking and cringing after I got home because what I may have said, has gone away. Feeling almost hyper active and intense when in a group situation, almost gone. Road rage....work in progress! Hahaha. Sex drive has diminished but this might be a good thing as was obsessive about it before. Less pressure. Wish I had started a lot earlier. Thought my anxiety was part of my personality, but the reality is, without it, I'm back to me again."

• Taken for 5 to 10 years
• April 17, 2019

"I have been on zoloft now for 7 years. In that time I stopped taking it 2 times. I have diagnosed social anxiety and OCD. Here is what I can tell you. When I started to take Zoloft I was 18 years old. The first month it did little, but after that it changed my life. I became more social. Intrusive thoughts are gone. I have control over my life. I stopped taking them twice because I thought that I’m cured. The withdrawal was both times somewhat manic. But after a few months all my symptoms came back. I had come to a conclusion that I just need Zoloft to function. If it’s for life to be functional then so it be. Life is much better with these medication. For all people that are new to this drug you must know that it takes some time to kick in. But like I said, it is worth it. Side effects for me are occasional - can sleep more than 8 hours, but yet again, I was always a good sleeper. Wish you all the best. My dose 100mg"

• April 6, 2020

"Generalised Anxiety Disorder: 24 year old, never suffered with anxiety, panic attacks or disturbing intrusive thoughts before - I was terrified, didn’t understand what was going on. I initially took time off work, CBT, counselling, meditation, reiki and Propranolol to help myself at first. Nothing took it away, so I made the decision to go onto Zoloft. The first 2 weeks, you HAVE to push through the side effects. I was constantly nauseous and at times I would vomit. But now, I’m completely back to my old self! Zoloft has really restored my mental health to the point where I am free of anxiety completely! I’ve also always had terrible PMT since I was a teenager, I have noticed that Zoloft has sorted this out for me too! When that time of the month is approaching usually, I become extremely angry and often cry about irrational things. Since being on Zoloft, I have noticed I am much calmer and happier around my cycle. It’s been like a wonder drug for me!"

• October 20, 2016

"Maybe my experience can help someone else... I have just completed a 30 day supply of Zoloft. My anxiety has been debilitating since my Multiple Sclerosis diagnosis in October of 2015. It became so bad that I was becoming bed ridden, afraid to leave my home. As a mother of 3 and a wife and daughter, my family needed me and I wasn't able to be there. I finally told my husband and parents I needed to seek help. After a therapy session and a visit with my family doctor I was given Zoloft. I received it on a Tuesday but was so afraid to take it, I didn't take my first one until Friday (I had read a few bad drug reviews, so I knew some things I could expect, but chose to focus on all the success stories for motivation.) For three weeks it was rough. Also must note, during this time we were hit with hurricane Matthew which didn't help and I believe set me back a few days. My side effects were tummy aches, diarrhea (sometimes 4 or 5 times a day), a few hot flashes, a couple days of zombie feeling, and I had 2 bad panic attacks. I know this sounds horrible, however, my opinion is that I felt as though I had hit rock bottom which is why I turned to medication. I already felt bad, so my commitment was to see this medicine through to the 4-6 week mark as instructed. If I had stopped taking it, I still would have felt horrible, that is what my life had become. With the wonderful support of my children and husband, a lot of take out food, and my parents helping to take and pick up my kids from school, I am SOOOOOO thankful I stuck with it and made it to the 4 week mark. I feel like I'm getting my life back. It is worth everything you go through. In full disclosure, some people get no side effects... my 20 year old son has been on Zoloft for a year and never had one side effect. I wasn't that lucky and seemed to have most. Please give yourself the chance. You will read over and over again to stick with it until 4-6 weeks... you must do yourself that favor. Surround yourself with support if you can and just do it! I'm so blessed to have my life back!!!!!"

• Taken for 2 to 5 years
• May 6, 2017

"I have been on Zoloft 25-150 mg for over 2 years. This has been the BEST 2 years of your life. Let me say that it took at least 90 days to really kick in and side effects to abate. If you have spent YEARS obsessed about your every action and thought, fearful and angry, depressed the 90 days of side effects is NOTHING. NOW if you want to keep living the way you are living because of dreams, diarrhea , INITIAL loss of appetite and weight loss then so be it. Improvement takes time. I was a 10 year Paxil user. Have TRIED lithium, Prozac, Luvox, tegretol, Xanax, Valuim, Alcohol, illegal drugs, supplements, buspar, kolonopin and on and on. ZOLOFT gives me a chance at life. I am still me with growing up issues at 50 plus but man this ZOLOFT is the deal."

• December 5, 2014

"I was born 1982 and throughout my adult life I have had problems with anxiety. I only really knew the true extent of how bad I was until I started taking 50mg of sertraline a couple of weeks ago. I went through my life self medicating whether it was alcohol or going for 8 mile runs just so I could relax. I realize now I heard the word "paranoid" pretty often which I now realize is very close to being anxious for obvious reasons. What strikes me about some of these reviews is many say its taken weeks to kick in. I suppose everyone is different but I felt my life change after 1 hour after taking a tablet. I now have an aura of calmness in my life. I feel like I'm at peace and living within the moment for the first time in years."

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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